Literature DB >> 21909124

The impact of cellular senescence in cancer therapy: is it true or not?

Yi Zhang1, Jin-ming Yang.   

Abstract

Cellular senescence is defined as the physiological program of terminal growth arrest, which can be triggered by various endogenous or exogenous stress signals. Cellular senescence can be induced in response to oncogenic activation and acts as a barrier to tumorigenesis. Moreover, tumor cells can undergo senescence when exposed to chemotherapeutic agents. In addition to suppressing tumorigenesis, senescent cells remain metabolically active and may contribute to tumor formation and to therapy resistance. In the current review, we discuss the molecular regulation of cellular senescence, the potential implications of senescence in human cancers, and the possibility of exploiting cellular senescence for the treatment of cancers.

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Year:  2011        PMID： 21909124      PMCID： PMC3760423          DOI： 10.1038/aps.2011.108

Source DB:  PubMed          Journal:  Acta Pharmacol Sin        ISSN： 1671-4083            Impact factor:   6.150


  94 in total

1.  Coexpression of NRASQ61R and BRAFV600E in human melanoma cells activates senescence and increases susceptibility to cell-mediated cytotoxicity.

Authors:  Carlotta Petti; Alessandra Molla; Claudia Vegetti; Soldano Ferrone; Andrea Anichini; Marialuisa Sensi
Journal:  Cancer Res       Date:  2006-07-01       Impact factor: 12.701

2.  A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

Authors:  P Mathijs Voorhoeve; Carlos le Sage; Mariette Schrier; Ad J M Gillis; Hans Stoop; Remco Nagel; Ying-Poi Liu; Josyanne van Duijse; Jarno Drost; Alexander Griekspoor; Eitan Zlotorynski; Norikazu Yabuta; Gabriella De Vita; Hiroshi Nojima; Leendert H J Looijenga; Reuven Agami
Journal:  Cell       Date:  2006-03-24       Impact factor: 41.582

3.  A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.

Authors:  B D Chang; E V Broude; M Dokmanovic; H Zhu; A Ruth; Y Xuan; E S Kandel; E Lausch; K Christov; I B Roninson
Journal:  Cancer Res       Date:  1999-08-01       Impact factor: 12.701

4.  Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

Authors:  M Serrano; A W Lin; M E McCurrach; D Beach; S W Lowe
Journal:  Cell       Date:  1997-03-07       Impact factor: 41.582

5.  Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process.

Authors:  Daniel R Radiloff; Timothy P Wakeman; Junjie Feng; Stephen Schilling; Edward Seto; Xiao-Fan Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-30       Impact factor: 11.205

6.  A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation.

Authors:  Masashi Narita; Masako Narita; Valery Krizhanovsky; Sabrina Nuñez; Agustin Chicas; Stephen A Hearn; Michael P Myers; Scott W Lowe
Journal:  Cell       Date:  2006-08-11       Impact factor: 41.582

7.  HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma.

Authors:  D Polsky; B C Bastian; C Hazan; K Melzer; J Pack; A Houghton; K Busam; C Cordon-Cardo; I Osman
Journal:  Cancer Res       Date:  2001-10-15       Impact factor: 12.701

8.  Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction.

Authors:  Lynne W Elmore; Catherine W Rehder; Xu Di; Patricia A McChesney; Colleen K Jackson-Cook; David A Gewirtz; Shawn E Holt
Journal:  J Biol Chem       Date:  2002-07-05       Impact factor: 5.157

9.  Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry.

Authors:  Julien Sage; Abigail L Miller; Pedro A Pérez-Mancera; Julianne M Wysocki; Tyler Jacks
Journal:  Nature       Date:  2003-07-10       Impact factor: 49.962

Review 10.  Telomerase and cancer therapeutics.

Authors:  Calvin B Harley
Journal:  Nat Rev Cancer       Date:  2008-03       Impact factor: 60.716
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  7 in total

1.  The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1.

Authors:  Kifayat Ullah; Suping Chen; Jiaqi Lu; Xiaohui Wang; Qing Liu; Yang Zhang; Yaqiu Long; Zhanhong Hu; Guoqiang Xu
Journal:  J Biol Chem       Date:  2020-02-10       Impact factor: 5.157

Review 2.  Friend or foe: the role of microRNA in chemotherapy resistance.

Authors:  Haoran Li; Burton B Yang
Journal:  Acta Pharmacol Sin       Date:  2013-04-29       Impact factor: 6.150

3.  Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells.

Authors:  Karolina Weiner-Gorzel; Eugene Dempsey; Malgorzata Milewska; Aloysius McGoldrick; Valerie Toh; Aoibheann Walsh; Sinead Lindsay; Luke Gubbins; Aoife Cannon; Daniel Sharpe; Jacintha O'Sullivan; Madeline Murphy; Stephen F Madden; Malcolm Kell; Amanda McCann; Fiona Furlong
Journal:  Cancer Med       Date:  2015-02-15       Impact factor: 4.452

4.  Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.

Authors:  Alan E Bilsland; Angelo Pugliese; Yu Liu; John Revie; Sharon Burns; Carol McCormick; Claire J Cairney; Justin Bower; Martin Drysdale; Masashi Narita; Mahito Sadaie; W Nicol Keith
Journal:  Neoplasia       Date:  2015-09       Impact factor: 5.715

5.  The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells.

Authors:  Hui-Ching Chuang; Liang Peng Yang; Alison L Fitzgerald; Abdullah Osman; Sang Hyeok Woo; Jeffrey N Myers; Heath D Skinner
Journal:  PLoS One       Date:  2014-08-13       Impact factor: 3.240

6.  Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe.

Authors:  Elodie A Pérès; Aurélie N Gérault; Samuel Valable; Simon Roussel; Jérôme Toutain; Didier Divoux; Jean-Sébastien Guillamo; Marc Sanson; Myriam Bernaudin; Edwige Petit
Journal:  Oncotarget       Date:  2015-02-10

7.  P53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene treatment.

Authors:  Rong-Jane Chen; Pei-Hsuan Wu; Chi-Tang Ho; Tzong-Der Way; Min-Hsiung Pan; Hsiu-Min Chen; Yuan-Soon Ho; Ying-Jan Wang
Journal:  Cell Death Dis       Date:  2017-08-10       Impact factor: 8.469
  7 in total

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