OBJECTIVES: To assess the diagnostic performance of whole-body magnetic resonance imaging (WB-MRI) by diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in malignant tumor detection and the potential diagnostic advantages in generating fused DWIBS/3D-contrast enhanced T1w (3D-CE-T1w) images. METHODS: 45 cancer patients underwent 18F-FDG PET-CT and WB-MRI for staging purpose. Fused DWIBS/3D-CE T1w images were generated off-line. 3D-CE-T1w, DWIBS images alone and fused with 3D-CE T1w were compared by two readers groups for detection of primary diseases and local/distant metastases. Diagnostic performance between the three WB-MRI data sets was assessed using receiver operating characteristic (ROC) curve analysis. Imaging exams and histopathological results were used as standard of references. RESULTS: Areas under the ROC curves of DWIBS vs. 3D-CE-T1w vs. both sequences in fused fashion were 0.97, 0.978, and 1.00, respectively. The diagnostic performance in tumor detection of fused DWIBS/3D-CE-T1w images were statistically superior to DWIBS (p<0.001) and 3D-CE-T1w (p≤0.002); while the difference between DWIBS and 3D-CE-T1w did not show statistical significance difference. Detection rates of malignancy did not differ between WB-MRI with DWIBS and 18F-FDG PET-CT. CONCLUSION: WB-MRI with DWIBS is to be considered as alternative tool to conventional whole-body methods for tumor staging and during follow-up in cancer patients.
OBJECTIVES: To assess the diagnostic performance of whole-body magnetic resonance imaging (WB-MRI) by diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in malignant tumor detection and the potential diagnostic advantages in generating fused DWIBS/3D-contrast enhanced T1w (3D-CE-T1w) images. METHODS: 45 cancerpatients underwent 18F-FDG PET-CT and WB-MRI for staging purpose. Fused DWIBS/3D-CE T1w images were generated off-line. 3D-CE-T1w, DWIBS images alone and fused with 3D-CE T1w were compared by two readers groups for detection of primary diseases and local/distant metastases. Diagnostic performance between the three WB-MRI data sets was assessed using receiver operating characteristic (ROC) curve analysis. Imaging exams and histopathological results were used as standard of references. RESULTS: Areas under the ROC curves of DWIBS vs. 3D-CE-T1w vs. both sequences in fused fashion were 0.97, 0.978, and 1.00, respectively. The diagnostic performance in tumor detection of fused DWIBS/3D-CE-T1w images were statistically superior to DWIBS (p<0.001) and 3D-CE-T1w (p≤0.002); while the difference between DWIBS and 3D-CE-T1w did not show statistical significance difference. Detection rates of malignancy did not differ between WB-MRI with DWIBS and 18F-FDG PET-CT. CONCLUSION: WB-MRI with DWIBS is to be considered as alternative tool to conventional whole-body methods for tumor staging and during follow-up in cancerpatients.
Authors: A Akbarzadeh; D Gutierrez; A Baskin; M R Ay; A Ahmadian; N Riahi Alam; K O Lövblad; H Zaidi Journal: J Appl Clin Med Phys Date: 2013-07-08 Impact factor: 2.102
Authors: Thomas E Yankeelov; Todd E Peterson; Richard G Abramson; David Izquierdo-Garcia; David Garcia-Izquierdo; Lori R Arlinghaus; Xia Li; Nkiruka C Atuegwu; Ciprian Catana; H Charles Manning; Zahi A Fayad; John C Gore Journal: Magn Reson Imaging Date: 2012-07-15 Impact factor: 2.546
Authors: L Liebsch; S Kailayangiri; L Beck; B Altvater; R Koch; C Dierkes; M Hotfilder; N Nagelmann; C Faber; H Kooijman; J Ring; V Vieth; C Rossig Journal: Br J Cancer Date: 2013-07-09 Impact factor: 7.640