Literature DB >> 21907920

Short hairpin RNA screen reveals bromodomain proteins as novel targets in acute myeloid leukemia.

Gerd A Blobel1, Anna Kalota, Patricia V Sanchez, Martin Carroll.   

Abstract

Targeting chromatin regulators for the treatment of malignancies has shown great promise, but also revealed significant challenges. By employing an elegant shRNA screen and a selective pharmacological inhibitor, a recent study published in Nature establishes the bromodomain protein Brd4 as novel target in acute myeloid leukemia (AML).
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21907920      PMCID： PMC3659823          DOI： 10.1016/j.ccr.2011.08.019

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  11 in total

Review 1.  Bromodomain: an acetyl-lysine binding domain.

Authors:  Lei Zeng; Ming Ming Zhou
Journal:  FEBS Lett       Date:  2002-02-20       Impact factor: 4.124

2.  Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.

Authors:  Zhiyuan Yang; Jasper H N Yik; Ruichuan Chen; Nanhai He; Moon Kyoo Jang; Keiko Ozato; Qiang Zhou
Journal:  Mol Cell       Date:  2005-08-19       Impact factor: 17.970

3.  Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.

Authors:  Denis Houzelstein; Simon L Bullock; Denise E Lynch; Elena F Grigorieva; Valerie A Wilson; Rosa S P Beddington
Journal:  Mol Cell Biol       Date:  2002-06       Impact factor: 4.272

4.  The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

Authors:  Shaila Rahman; Mathew E Sowa; Matthias Ottinger; Jennifer A Smith; Yang Shi; J Wade Harper; Peter M Howley
Journal:  Mol Cell Biol       Date:  2011-05-09       Impact factor: 4.272

Review 5.  The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation.

Authors:  Shwu-Yuan Wu; Cheng-Ming Chiang
Journal:  J Biol Chem       Date:  2007-02-28       Impact factor: 5.157

6.  Suppression of inflammation by a synthetic histone mimic.

Authors:  Edwige Nicodeme; Kate L Jeffrey; Uwe Schaefer; Soren Beinke; Scott Dewell; Chun-Wa Chung; Rohit Chandwani; Ivan Marazzi; Paul Wilson; Hervé Coste; Julia White; Jorge Kirilovsky; Charles M Rice; Jose M Lora; Rab K Prinjha; Kevin Lee; Alexander Tarakhovsky
Journal:  Nature       Date:  2010-11-10       Impact factor: 49.962

7.  An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines.

Authors:  G Anfossi; A M Gewirtz; B Calabretta
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

8.  Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.

Authors:  Johannes Zuber; Katherine McJunkin; Christof Fellmann; Lukas E Dow; Meredith J Taylor; Gregory J Hannon; Scott W Lowe
Journal:  Nat Biotechnol       Date:  2010-12-05       Impact factor: 54.908

9.  RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.

Authors:  Johannes Zuber; Junwei Shi; Eric Wang; Amy R Rappaport; Harald Herrmann; Edward A Sison; Daniel Magoon; Jun Qi; Katharina Blatt; Mark Wunderlich; Meredith J Taylor; Christopher Johns; Agustin Chicas; James C Mulloy; Scott C Kogan; Patrick Brown; Peter Valent; James E Bradner; Scott W Lowe; Christopher R Vakoc
Journal:  Nature       Date:  2011-08-03       Impact factor: 49.962

10.  Selective inhibition of BET bromodomains.

Authors:  Panagis Filippakopoulos; Jun Qi; Sarah Picaud; Yao Shen; William B Smith; Oleg Fedorov; Elizabeth M Morse; Tracey Keates; Tyler T Hickman; Ildiko Felletar; Martin Philpott; Shonagh Munro; Michael R McKeown; Yuchuan Wang; Amanda L Christie; Nathan West; Michael J Cameron; Brian Schwartz; Tom D Heightman; Nicholas La Thangue; Christopher A French; Olaf Wiest; Andrew L Kung; Stefan Knapp; James E Bradner
Journal:  Nature       Date:  2010-09-24       Impact factor: 49.962
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  17 in total

Review 1.  BET domain co-regulators in obesity, inflammation and cancer.

Authors:  Anna C Belkina; Gerald V Denis
Journal:  Nat Rev Cancer       Date:  2012-06-22       Impact factor: 60.716

2.  CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.

Authors:  John Anto Pulikkan; Mahesh Hegde; Hafiz Mohd Ahmad; Houda Belaghzal; Anuradha Illendula; Jun Yu; Kelsey O'Hagan; Jianhong Ou; Carsten Muller-Tidow; Scot A Wolfe; Lihua Julie Zhu; Job Dekker; John Hackett Bushweller; Lucio Hernán Castilla
Journal:  Cell       Date:  2018-06-28       Impact factor: 41.582

Review 3.  Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia.

Authors:  Jianbiao Zhou; Wee-Joo Chng
Journal:  World J Stem Cells       Date:  2014-09-26       Impact factor: 5.326

4.  An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

Authors:  Birgit Knoechel; Justine E Roderick; Kaylyn E Williamson; Jiang Zhu; Jens G Lohr; Matthew J Cotton; Shawn M Gillespie; Daniel Fernandez; Manching Ku; Hongfang Wang; Federica Piccioni; Serena J Silver; Mohit Jain; Daniel Pearson; Michael J Kluk; Christopher J Ott; Leonard D Shultz; Michael A Brehm; Dale L Greiner; Alejandro Gutierrez; Kimberly Stegmaier; Andrew L Kung; David E Root; James E Bradner; Jon C Aster; Michelle A Kelliher; Bradley E Bernstein
Journal:  Nat Genet       Date:  2014-03-02       Impact factor: 38.330

5.  Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.

Authors:  Xiangming Hu; Xiaodong Lu; Runzhong Liu; Nanping Ai; Zhenhua Cao; Yannan Li; Jiangfang Liu; Bin Yu; Kai Liu; Huiping Wang; Chao Zhou; Yu Wang; Aidong Han; Feng Ding; Ruichuan Chen
Journal:  J Biol Chem       Date:  2014-06-17       Impact factor: 5.157

Review 6.  Emerging therapeutic drugs for AML.

Authors:  Eytan M Stein; Martin S Tallman
Journal:  Blood       Date:  2015-12-10       Impact factor: 22.113

Review 7.  Role of MYC in Medulloblastoma.

Authors:  Martine F Roussel; Giles W Robinson
Journal:  Cold Spring Harb Perspect Med       Date:  2013-11-01       Impact factor: 6.915

Review 8.  Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives.

Authors:  Federico Andreoli; Arménio Jorge Moura Barbosa; Marco Daniele Parenti; Alberto Del Rio
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.310

Review 9.  Recent progress in targeting cancer.

Authors:  Zoya N Demidenko; James A McCubrey
Journal:  Aging (Albany NY)       Date:  2011-12       Impact factor: 5.682

10.  Open access target validation is a more efficient way to accelerate drug discovery.

Authors:  Wen Hwa Lee
Journal:  PLoS Biol       Date:  2015-06-04       Impact factor: 8.029
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