Literature DB >> 21907918

DePICTing p53 activation: a new nucleolar link to cancer.

Lior Golomb1, Moshe Oren.   

Abstract

p53 activation by ribosomal biogenesis stress is important for tumor suppression. In the August issue of Nature Medicine, Sasaki et al. identify PICT1 as a regulator of this process. PICT1 sequesters ribosomal protein RPL11 in the nucleolus, attenuating p53 induction. Excessive PICT1 may dampen the p53 response and promote cancer.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21907918     DOI： 10.1016/j.ccr.2011.08.017

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  4 in total

1.  Get your fingers out of p53's way!

Authors:  Débora Rosa Bublik; Moshe Oren
Journal:  EMBO Rep       Date:  2012-04-02       Impact factor: 8.807

2.  Genetic influences on brain gene expression in rats selected for tameness and aggression.

Authors:  Henrike O Heyne; Susann Lautenschläger; Ronald Nelson; François Besnier; Maxime Rotival; Alexander Cagan; Rimma Kozhemyakina; Irina Z Plyusnina; Lyudmila Trut; Örjan Carlborg; Enrico Petretto; Leonid Kruglyak; Svante Pääbo; Torsten Schöneberg; Frank W Albert
Journal:  Genetics       Date:  2014-09-03       Impact factor: 4.562

3.  PICT1 expression is a poor prognostic factor in non-small cell lung cancer.

Authors:  Kyoko Okamura; Koichi Takayama; Kohichi Kawahara; Taishi Harada; Miki Nishio; Kohei Otsubo; Kayo Ijichi; Mikihiro Kohno; Eiji Iwama; Akiko Fujii; Keiichi Ota; Takaomi Koga; Tatsuro Okamoto; Akira Suzuki; Yoichi Nakanishi
Journal:  Oncoscience       Date:  2014-05-25

Review 4.  Recent discoveries in the cycling, growing and aging of the p53 field.

Authors:  James A McCubrey; Zoya N Demidenko
Journal:  Aging (Albany NY)       Date:  2012-12       Impact factor: 5.682
  4 in total

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