Literature DB >> 21907917

Ras, ROS and proteotoxic stress: a delicate balance.

Wanping Xu1, Jane Trepel, Len Neckers.   

Abstract

Ras-deregulated cells require reactive oxygen species for proliferation. They survive the resultant proteotoxic stress by maintaining sufficient levels of reduced glutathione and optimally functioning stress response machinery. In this issue of Cancer Cell, De Raedt et al. identify a novel strategy that utilizes this dependency to cause cell death.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21907917      PMCID： PMC3179373          DOI： 10.1016/j.ccr.2011.08.020

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  9 in total

1.  Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia-induced injury in H9c2 cardiac myocytes.

Authors:  Zhanli Yang; Chuntao Yang; Liangcan Xiao; Xinxue Liao; Aiping Lan; Xiuyu Wang; Ruixian Guo; Peixi Chen; Chengheng Hu; Jianqiang Feng
Journal:  Int J Mol Med       Date:  2011-04-20       Impact factor: 4.101

2.  Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.

Authors:  Frank Weinberg; Robert Hamanaka; William W Wheaton; Samuel Weinberg; Joy Joseph; Marcos Lopez; Balaraman Kalyanaraman; Gökhan M Mutlu; G R Scott Budinger; Navdeep S Chandel
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-26       Impact factor: 11.205

3.  Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin.

Authors:  Goh Ohji; Sujuti Hidayat; Akio Nakashima; Chiharu Tokunaga; Noriko Oshiro; Ken-Ichi Yoshino; Koichi Yokono; Ushio Kikkawa; Kazuyoshi Yonezawa
Journal:  J Biochem       Date:  2006-01       Impact factor: 3.387

Review 4.  New druggable targets in the Ras pathway?

Authors:  David Matallanas; Piero Crespo
Journal:  Curr Opin Mol Ther       Date:  2010-12

Review 5.  The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition.

Authors:  S Meloche; J Pouysségur
Journal:  Oncogene       Date:  2007-05-14       Impact factor: 9.867

6.  Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.

Authors:  Monica G Marcu; Melissa Doyle; Anne Bertolotti; David Ron; Linda Hendershot; Len Neckers
Journal:  Mol Cell Biol       Date:  2002-12       Impact factor: 4.272

7.  Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions.

Authors:  Martin L Sos; Kathrin Michel; Thomas Zander; Jonathan Weiss; Peter Frommolt; Martin Peifer; Danan Li; Roland Ullrich; Mirjam Koker; Florian Fischer; Takeshi Shimamura; Daniel Rauh; Craig Mermel; Stefanie Fischer; Isabel Stückrath; Stefanie Heynck; Rameen Beroukhim; William Lin; Wendy Winckler; Kinjal Shah; Thomas LaFramboise; Whei F Moriarty; Megan Hanna; Laura Tolosi; Jörg Rahnenführer; Roel Verhaak; Derek Chiang; Gad Getz; Martin Hellmich; Jürgen Wolf; Luc Girard; Michael Peyton; Barbara A Weir; Tzu-Hsiu Chen; Heidi Greulich; Jordi Barretina; Geoffrey I Shapiro; Levi A Garraway; Adi F Gazdar; John D Minna; Matthew Meyerson; Kwok-Kin Wong; Roman K Thomas
Journal:  J Clin Invest       Date:  2009-05-18       Impact factor: 14.808

Review 8.  Targeting RAS signalling pathways in cancer therapy.

Authors:  Julian Downward
Journal:  Nat Rev Cancer       Date:  2003-01       Impact factor: 60.716

Review 9.  Clinical and genetic aspects of neurofibromatosis 1.

Authors:  Kimberly Jett; Jan M Friedman
Journal:  Genet Med       Date:  2010-01       Impact factor: 8.822
  9 in total
  18 in total

1.  Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression.

Authors:  Zhengzhao Liu; Peng Chen; Hong Gao; Yu Gu; Jiao Yang; Hong Peng; Xingxing Xu; Haifeng Wang; Meiqiang Yang; Xiaoying Liu; Libin Fan; Shiyao Chen; Jian Zhou; Yihong Sun; Kangchen Ruan; Shuqun Cheng; Masaaki Komatsu; Eileen White; Lin Li; Hongbin Ji; Daniel Finley; Ronggui Hu
Journal:  Cancer Cell       Date:  2014-07-14       Impact factor: 31.743

2.  Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light.

Authors:  Hannah Serrage; Vladimir Heiskanen; William M Palin; Paul R Cooper; Michael R Milward; Mohammed Hadis; Michael R Hamblin
Journal:  Photochem Photobiol Sci       Date:  2019-06-11       Impact factor: 3.982

3.  The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.

Authors:  Angela L Davis; Shuxi Qiao; Jessica L Lesson; Montserrat Rojo de la Vega; Sophia L Park; Carol M Seanez; Vijay Gokhale; Christopher M Cabello; Georg T Wondrak
Journal:  J Biol Chem       Date:  2014-12-04       Impact factor: 5.157

4.  Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes.

Authors:  Shuxi Qiao; Sarah D Lamore; Christopher M Cabello; Jessica L Lesson; José L Muñoz-Rodriguez; Georg T Wondrak
Journal:  Biochem Pharmacol       Date:  2012-02-01       Impact factor: 5.858

5.  D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis.

Authors:  Shuxi Qiao; Christopher M Cabello; Sarah D Lamore; Jessica L Lesson; Georg T Wondrak
Journal:  Apoptosis       Date:  2012-10       Impact factor: 4.677

6.  Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways.

Authors:  Patrick T Grogan; Kristina D Sleder; Abbas K Samadi; Huaping Zhang; Barbara N Timmermann; Mark S Cohen
Journal:  Invest New Drugs       Date:  2012-11-06       Impact factor: 3.850

7.  Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells.

Authors:  Jae Won Choi; Mark A Schroeder; Jann N Sarkaria; Richard J Bram
Journal:  Cancer Res       Date:  2013-11-22       Impact factor: 12.701

Review 8.  Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy.

Authors:  S V Alarcon; M Mollapour; M-J Lee; S Tsutsumi; S Lee; Y S Kim; T Prince; A B Apolo; G Giaccone; W Xu; L M Neckers; J B Trepel
Journal:  Curr Mol Med       Date:  2012-11-01       Impact factor: 2.222

9.  Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling.

Authors:  Takushi Namba; Rika Kodama
Journal:  Mar Drugs       Date:  2015-04-16       Impact factor: 5.118

10.  Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer.

Authors:  Xiaomei Qi; Congying Xie; Songwang Hou; Gang Li; Ning Yin; Lei Dong; Adrienne Lepp; Marla A Chesnik; Shama P Mirza; Aniko Szabo; Susan Tsai; Zainab Basir; Shixiu Wu; Guan Chen
Journal:  Oncotarget       Date:  2014-06-30
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