AIM: To evaluate changes in prevalence of an epidemic strain of Pseudomonas aeruginosa (AES-1, Australian epidemic strain, type 1) in a paediatric cystic fibrosis (CF) centre practising cohort segregation, to describe the patients' clinical characteristics at acquisition and observe mortality rates. METHODS: Cohort segregation was introduced in our paediatric CF clinic January 2000. The prevalence of AES-1 was analysed in 1999, 2002 and 2007. Age at acquisition, lung function, presence of bronchiectasis, hospitalisations, prior P. aeruginosa infection and mortality rates were collected. AES-1 infection was determined by pulse-field-gel-electrophoresis (PFGE) on airway specimen cultures taken three monthly. RESULTS: The prevalence of AES-1 declined from 21% in 1999 to 14% in 2002 (risk difference 7% (95% CI 1,13) p=0.0256) and to 6% in 2007 (risk difference 8% (95% CI 3,13) p=0.0018). New acquisitions after the introduction of cohort segregation were uncommon (10 by 2002 and another 7 by 2007) with a declining incidence of 3.3 cases/year (1999 to 2002) compared to 1.4 cases/year (2002 to 2007). Twenty-two of 32 (69%) deaths between 1999 and 2007 occurred in patients infected with AES-1. CONCLUSION: Cohort segregation has been associated with reductions in the prevalence of AES-1 in our CF clinic. Mortality was higher in patients infected with AES-1 than other organisms.
AIM: To evaluate changes in prevalence of an epidemic strain of Pseudomonas aeruginosa (AES-1, Australian epidemic strain, type 1) in a paediatric cystic fibrosis (CF) centre practising cohort segregation, to describe the patients' clinical characteristics at acquisition and observe mortality rates. METHODS: Cohort segregation was introduced in our paediatric CF clinic January 2000. The prevalence of AES-1 was analysed in 1999, 2002 and 2007. Age at acquisition, lung function, presence of bronchiectasis, hospitalisations, prior P. aeruginosa infection and mortality rates were collected. AES-1infection was determined by pulse-field-gel-electrophoresis (PFGE) on airway specimen cultures taken three monthly. RESULTS: The prevalence of AES-1 declined from 21% in 1999 to 14% in 2002 (risk difference 7% (95% CI 1,13) p=0.0256) and to 6% in 2007 (risk difference 8% (95% CI 3,13) p=0.0018). New acquisitions after the introduction of cohort segregation were uncommon (10 by 2002 and another 7 by 2007) with a declining incidence of 3.3 cases/year (1999 to 2002) compared to 1.4 cases/year (2002 to 2007). Twenty-two of 32 (69%) deaths between 1999 and 2007 occurred in patients infected with AES-1. CONCLUSION: Cohort segregation has been associated with reductions in the prevalence of AES-1 in our CF clinic. Mortality was higher in patients infected with AES-1 than other organisms.
Authors: Christy Kim; Elizabeth delaRiva-Velasco; Arvind Budhram; Folashade Farri; Daniel Krich; Sheila S Nolan; Suzette Gjonaj; Lisa Paul; Allen J Dozor; John J Welter Journal: J Infect Prev Date: 2019-09-25
Authors: Christopher J Harmer; Matthew Wynn; Rachel Pinto; Stuart Cordwell; Barbara R Rose; Colin Harbour; James A Triccas; Jim Manos Journal: PLoS One Date: 2015-08-07 Impact factor: 3.240
Authors: Rosa van Mansfeld; Angelica de Vrankrijker; Roland Brimicombe; Harry Heijerman; Ferdinand Teding van Berkhout; Cristian Spitoni; Sanne Grave; Cornelis van der Ent; Tom Wolfs; Rob Willems; Marc Bonten Journal: PLoS One Date: 2016-06-09 Impact factor: 3.240