Literature DB >> 21906874

Mesenchymal stromal cells may enhance metastasis of neuroblastoma via SDF-1/CXCR4 and SDF-1/CXCR7 signaling.

Ming Ma1, Jie Yu Ye, Ruixia Deng, Cathleen Michelle Dee, Godfrey Chi-Fung Chan.   

Abstract

Bone marrow metastasis is frequently observed in patients with high-risk neuroblastoma. Mesenchymal stromal cells (MSCs) in bone marrow may enhance tumor metastasis through secreting stromal cell-derived factor-1 (SDF-1). Here we investigated neuroblastoma cell behaviors under the influence of MSCs and explored the function of SDF-1 signaling during metastasis. Neuroblastoma expressed both of the SDF-1 receptors CXCR4 and CXCR7. shRNA knockdown showed that these receptors were responsible for the migration of neuroblastoma towards MSCs. CXCR4 also supported neuroblastoma invasion. These effects could be effectively blocked by AMD3100, a potent SDF-1 antagonist. Our study suggests that MSCs are important for neuroblastoma metastasis via the secretion of SDF-1 and that such effect can be inhibited by AMD3100 or shRNA knockdown.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21906874     DOI： 10.1016/j.canlet.2011.06.028

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  36 in total

1.  Targeting the CXCR4/CXCL12 axis in treating epithelial ovarian cancer.

Authors:  T L Mao; K F Fan; C L Liu
Journal:  Gene Ther       Date:  2017-09-07       Impact factor: 5.250

Review 2.  Role of BMSCs in liver regeneration and metastasis after hepatectomy.

Authors:  Hua-Lian Hang; Qiang Xia
Journal:  World J Gastroenterol       Date:  2014-01-07       Impact factor: 5.742

3.  Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal stem cells promote, glioblastoma multiforme proliferation.

Authors:  Keiko Akimoto; Kenichi Kimura; Masumi Nagano; Shingo Takano; Georgina To'a Salazar; Toshiharu Yamashita; Osamu Ohneda
Journal:  Stem Cells Dev       Date:  2013-02-04       Impact factor: 3.272

4.  SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis.

Authors:  Karthik M Kodigepalli; Serena Bonifati; Nagaraja Tirumuru; Li Wu
Journal:  Cell Cycle       Date:  2018-07-17       Impact factor: 4.534

5.  Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma.

Authors:  Melanie A Krook; Lauren A Nicholls; Christopher A Scannell; Rashmi Chugh; Dafydd G Thomas; Elizabeth R Lawlor
Journal:  Mol Cancer Res       Date:  2014-03-20       Impact factor: 5.852

Review 6.  More than the genes, the tumor microenvironment in neuroblastoma.

Authors:  Lucia Borriello; Robert C Seeger; Shahab Asgharzadeh; Yves A DeClerck
Journal:  Cancer Lett       Date:  2015-11-17       Impact factor: 8.679

7.  Establishment and characterization of xenograft models of human neuroblastoma bone metastasis.

Authors:  Hongyu Zhao; Weisong Cai; Shuai Li; Zuke Da; Hanxue Sun; Liang Ma; Yaoxin Lin; Debao Zhi
Journal:  Childs Nerv Syst       Date:  2012-09-16       Impact factor: 1.475

8.  Characterization of neuroblastoma bone invasion/metastasis in established bone metastatic model of SY5Y and KCNR cell lines.

Authors:  Hongyu Zhao; Weisong Cai; Shuai Li; Zuke Da; Hanxue Sun; Liang Ma; Yaoxin Lin; Debao Zhi
Journal:  Childs Nerv Syst       Date:  2013-04-05       Impact factor: 1.475

Review 9.  Immune regulation by atypical chemokine receptors.

Authors:  Robert J B Nibbs; Gerard J Graham
Journal:  Nat Rev Immunol       Date:  2013-11       Impact factor: 53.106

Review 10.  Importance of the origin of mesenchymal (stem) stromal cells in cancer biology: "alliance" or "war" in intercellular signals.

Authors:  Noemi Eiro; Maria Fraile; Silvia Fernández-Francos; Rosario Sánchez; Luis A Costa; Francisco J Vizoso
Journal:  Cell Biosci       Date:  2021-06-10       Impact factor: 7.133
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.