Literature DB >> 21906854

Synthesis and antimicrobial activity of amido linked pyrrolyl and pyrazolyl-oxazoles, thiazoles and imidazoles.

V Padmavathi1, C Prema Kumari, B C Venkatesh, A Padmaja.   

Abstract

A new class of amido linked bis heterocycles viz., pyrrolyl/pyrazolyl-oxazoles, thiazoles and imidazoles were prepared by 1,3-dipolar cycloaddition of TosMIC and diazomethane to the respective cinnamamide derivatives and screened for antimicrobial activity. The chlorosubstituted imidazolyl cinnamamide (6c) is the most potential antimicrobial agent as it displayed strong antibacterial activity against Bacillus subtilis and antifungal activity against Penicillium chrysogenum.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.

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Year:  2011        PMID： 21906854     DOI： 10.1016/j.ejmech.2011.08.032

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  9 in total

1.  2-(chromon-3-yl)imidazole derivatives as potential antimicrobial agents: synthesis, biological evaluation and molecular docking studies.

Authors:  Shweta Sharma; Vishal Sharma; Gurpreet Singh; Harpreet Kaur; Shubham Srivastava; Mohan Paul S Ishar
Journal:  J Chem Biol       Date:  2016-11-16

Review 2.  An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety.

Authors:  Renzo Rossi; Maurizio Ciofalo
Journal:  Molecules       Date:  2020-11-04       Impact factor: 4.411

Review 3.  Imidazoles as potential anticancer agents.

Authors:  Imran Ali; Mohammad Nadeem Lone; Haasan Y Aboul-Enein
Journal:  Medchemcomm       Date:  2017-04-13       Impact factor: 3.597

4.  Design, synthesis, DFT, docking studies and ADME prediction of some new coumarinyl linked pyrazolylthiazoles: Potential standalone or adjuvant antimicrobial agents.

Authors:  Sunil Kumar; Vikram Saini; Indresh K Maurya; Jayant Sindhu; Mukesh Kumari; Ramesh Kataria; Vinod Kumar
Journal:  PLoS One       Date:  2018-04-19       Impact factor: 3.240

5.  [3+2] Cycloaddition of Tosylmethyl Isocyanide with Styrylisoxazoles: Facile Access to Polysubstituted 3-(Isoxazol-5-yl)pyrroles.

Authors:  Xueming Zhang; Xianxiu Xu; Dawei Zhang
Journal:  Molecules       Date:  2017-07-07       Impact factor: 4.411

6.  Design, synthesis and biological potential of heterocyclic benzoxazole scaffolds as promising antimicrobial and anticancer agents.

Authors:  Saloni Kakkar; Sanjiv Kumar; Balasubramanian Narasimhan; Siong Meng Lim; Kalavathy Ramasamy; Vasudevan Mani; Syed Adnan Ali Shah
Journal:  Chem Cent J       Date:  2018-09-19       Impact factor: 4.215

7.  Synthesis, Antimicrobial and cytotoxic activity of New Heterocyclic Hybrids Based on 2,5-Dimethylpyrrole and Pyrrole Scaffolds.

Authors:  S D Joshi; U A More; V H Kulkarni
Journal:  Indian J Pharm Sci       Date:  2013-05       Impact factor: 0.975

Review 8.  Synthesis of Multi-Substituted Pyrrole Derivatives Through [3+2] Cycloaddition with Tosylmethyl Isocyanides (TosMICs) and Electron-Deficient Compounds.

Authors:  Zhengning Ma; Zicheng Ma; Dawei Zhang
Journal:  Molecules       Date:  2018-10-17       Impact factor: 4.411

9.  Benzoxazole derivatives: design, synthesis and biological evaluation.

Authors:  Saloni Kakkar; Sumit Tahlan; Siong Meng Lim; Kalavathy Ramasamy; Vasudevan Mani; Syed Adnan Ali Shah; Balasubramanian Narasimhan
Journal:  Chem Cent J       Date:  2018-08-12       Impact factor: 4.215
  9 in total

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