| Literature DB >> 21905888 |
Karen L Marino1, Ibrahim Zakhary, Rafik A Abdelsayed, Jared A Carter, Jack C O'Neill, Rania M Khashaba, Mohammed Elsalanty, Mark R Stevens, James L Borke.
Abstract
The purpose of this study was to develop a rat model predictive of bisphosphonate-related osteonecrosis of the jaw (BRONJ) after exodontias. Thirty female rats were randomized into 2 groups, control and experimental. The experimental group received 2 intravenous injections of zoledronate (20 μg/kg). The mesial root of the right mandibular first molar was extracted. Rats were euthanized at 0, 4, and 8 weeks. Bone mineral density (BMD), collagen breakdown (pyridinium [PYD]), vascular regeneration (VEGF), and histology were examined. A trend toward higher PYD values was suggested in control vs experimental groups after wounding. Serum VEGF increased significantly after wounding for both control and experimental groups. After 8 weeks, VEGF continued to rise for the experimental group only. In the extraction socket area, BMD was significantly lower after wounding in control vs. zoledronate-treated rats. Histology sections from experimental groups showed bacteria and bone necrosis. Consistent findings of BRONJ features similar to those in humans were observed after zoledronate treatment.Entities:
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Year: 2011 PMID： 21905888 DOI： 10.1563/AAID-JOI-D-11-00057
Source DB: PubMed Journal: J Oral Implantol ISSN： 0160-6972 Impact factor: 1.779