Hyun Kyung Cho1, Myoung Hee Park, Jung Il Moon. 1. Department of Ophthalmology and Visual Science, St. Mary's Hospital, The Catholic University of Korea, #62 Yeouido-dong, Yeongdeungpo-gu, Seoul 150-713, Korea.
Abstract
PURPOSE: We investigated the effects of a fixed-combination antiglaucoma drug and compared it with two concomitant antiglaucoma drugs on the ocular surface. METHODS: Twenty-four rabbits were randomized into four groups. Group 1 was administered timolol, group 2 travoprost, group 3 a travoprost/timolol fixed-combination solution, and group 4 timolol and travoprost. Conjunctival impression cytology specimens were collected at baseline and weeks 1, 3, and 6, and conjunctival biopsy specimens at week 6. RESULTS: The impression cytology study results were as follows: No statistically significant differences among group 1-3 at any time (p > 0.05); a statistically significant difference between groups 3 and 4 at week 6 (p = 0.003); a statistically significant difference between baseline and group 4 at week 6 (p = 0.008). Conjunctival biopsy specimens of group 1-3 showed no distortion of the conjunctival epithelial structures, but group 4 showed decreased layers of epithelial cells with fewer periodic acid-Schiff (PAS) (+) goblet cells. CONCLUSIONS: A fixed-combination antiglaucoma drug is beneficial in reducing adverse ocular surface changes in long-term use. This is believed to be due to the smaller concentration of preservatives contained in the fixed-combination drug.
PURPOSE: We investigated the effects of a fixed-combination antiglaucoma drug and compared it with two concomitant antiglaucoma drugs on the ocular surface. METHODS: Twenty-four rabbits were randomized into four groups. Group 1 was administered timolol, group 2 travoprost, group 3 a travoprost/timolol fixed-combination solution, and group 4 timolol and travoprost. Conjunctival impression cytology specimens were collected at baseline and weeks 1, 3, and 6, and conjunctival biopsy specimens at week 6. RESULTS: The impression cytology study results were as follows: No statistically significant differences among group 1-3 at any time (p > 0.05); a statistically significant difference between groups 3 and 4 at week 6 (p = 0.003); a statistically significant difference between baseline and group 4 at week 6 (p = 0.008). Conjunctival biopsy specimens of group 1-3 showed no distortion of the conjunctival epithelial structures, but group 4 showed decreased layers of epithelial cells with fewer periodic acid-Schiff (PAS) (+) goblet cells. CONCLUSIONS: A fixed-combination antiglaucoma drug is beneficial in reducing adverse ocular surface changes in long-term use. This is believed to be due to the smaller concentration of preservatives contained in the fixed-combination drug.
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