Literature DB >> 21904761

The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins).

Daniel Krahn1, Christian Ottmann, Markus Kaiser.   

Abstract

Syrbactin is a subordinate term for the syringolin, glidobactin and cepafungin natural product families. Their grouping is based on their related molecular frameworks, similar biosynthesis pathways and, most importantly, identical modes-of-action, being irreversible proteasome inhibition. With this report, we aim to review their chemical biology, describing their common, but also differential characteristics.

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Year:  2011        PMID： 21904761     DOI： 10.1039/c1np00048a

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  13 in total

Review 1.  Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds.

Authors:  Christopher T Walsh; Robert V O'Brien; Chaitan Khosla
Journal:  Angew Chem Int Ed Engl       Date:  2013-05-31       Impact factor: 15.336

2.  Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.

Authors:  Kyle A Totaro; Dominik Barthelme; Peter T Simpson; Xiuju Jiang; Gang Lin; Carl F Nathan; Robert T Sauer; Jason K Sello
Journal:  ACS Infect Dis       Date:  2016-12-05       Impact factor: 5.084

3.  Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines.

Authors:  Kyle A Totaro; Dominik Barthelme; Peter T Simpson; Robert T Sauer; Jason K Sello
Journal:  Bioorg Med Chem       Date:  2015-07-26       Impact factor: 3.641

4.  Syrbactin proteasome inhibitor TIR-199 overcomes bortezomib chemoresistance and inhibits multiple myeloma tumor growth in vivo.

Authors:  Marquicia R Pierce; Reeder M Robinson; Tannya R Ibarra-Rivera; Michael C Pirrung; Nathan G Dolloff; André S Bachmann
Journal:  Leuk Res       Date:  2019-11-12       Impact factor: 3.156

5.  Burkholderia as a Source of Natural Products.

Authors:  Sylvia Kunakom; Alessandra S Eustáquio
Journal:  J Nat Prod       Date:  2019-07-11       Impact factor: 4.050

Review 6.  Harnessing proteasome dynamics and allostery in drug design.

Authors:  Maria Gaczynska; Pawel A Osmulski
Journal:  Antioxid Redox Signal       Date:  2014-02-21       Impact factor: 8.401

7.  One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor.

Authors:  Martin L Stein; Philipp Beck; Markus Kaiser; Robert Dudler; Christian F W Becker; Michael Groll
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-22       Impact factor: 11.205

8.  Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I.

Authors:  Alexander Amatuni; Anton Shuster; Alexander Adibekian; Hans Renata
Journal:  Cell Chem Biol       Date:  2020-08-06       Impact factor: 8.116

9.  Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.

Authors:  Michelle Schorn; Judith Zettler; Joseph P Noel; Pieter C Dorrestein; Bradley S Moore; Leonard Kaysser
Journal:  ACS Chem Biol       Date:  2013-11-08       Impact factor: 5.100

10.  Bioinformatics Analysis of the Complete Genome Sequence of the Mango Tree Pathogen Pseudomonas syringae pv. syringae UMAF0158 Reveals Traits Relevant to Virulence and Epiphytic Lifestyle.

Authors:  Pedro Manuel Martínez-García; Pablo Rodríguez-Palenzuela; Eva Arrebola; Víctor J Carrión; José Antonio Gutiérrez-Barranquero; Alejandro Pérez-García; Cayo Ramos; Francisco M Cazorla; Antonio de Vicente
Journal:  PLoS One       Date:  2015-08-27       Impact factor: 3.240
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