Literature DB >> 21903729

Hughlings Jackson's neurological ideas.

George K York1, David A Steinberg.   

Abstract

Hughlings Jackson's neurological ideas are scientifically valid and practically useful. He began by emphasizing the focal lesion as the key to analysing patients' symptoms. He proclaimed that 'Epilepsy is the name for occasional, sudden, excessive, rapid, and local discharge of grey matter.' He eliminated any need for a direct appeal to metaphysical agents by asserting that the nervous system is an exclusively sensorimotor machine constrained by the newly discovered conservation laws. In constructing his neurophysiology he accepted the phrenological assumption that the nervous system is composed of a number of physiologically discrete organs, each with a single function accessible to the diagnostician. By observing the march of epileptic seizures he developed the idea of somatotopic representation. He claimed that the nervous system is an evolutionary hierarchy of three levels connected by the process of weighted ordinal representation. His assertion of the Doctrine of Concomitance further separated the concerns, and the institutions, of the neurophysiologist from that of the psychiatrist. He came to reject the idea of the unconscious because he could not observe unequivocally unconscious behaviour at the bedside. Each of these ideas emerged from contemporaneous scientific streams, but Hughlings Jackson was the one to incorporate them into practical medicine. These neurological ideas gave physicians the methods, tools, principles and structures with which to establish a new science of clinical neurology.

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Year:  2011        PMID: 21903729     DOI: 10.1093/brain/awr219

Source DB:  PubMed          Journal:  Brain        ISSN: 0006-8950            Impact factor:   13.501


  16 in total

1.  Parallel pathways of seizure generalization.

Authors:  Natalia Dabrowska; Suchitra Joshi; John Williamson; Ewa Lewczuk; Yanhong Lu; Samrath Oberoi; Anastasia Brodovskaya; Jaideep Kapur
Journal:  Brain       Date:  2019-08-01       Impact factor: 13.501

2.  Hughlings Jackson on joking.

Authors:  George K York
Journal:  Brain       Date:  2015-04-01       Impact factor: 13.501

3.  Phenytoin: a step by step insight into its multiple mechanisms of action-80 years of mechanistic studies in neuropharmacology.

Authors:  Jan M Keppel Hesselink
Journal:  J Neurol       Date:  2017-03-27       Impact factor: 4.849

Review 4.  Dorsolateral frontal lobe epilepsy.

Authors:  Ricky W Lee; Greg A Worrell
Journal:  J Clin Neurophysiol       Date:  2012-10       Impact factor: 2.177

Review 5.  Pathways of translation: deep brain stimulation.

Authors:  Michael R Gionfriddo; Alexandra J Greenberg; Abhijeet L Wahegaonkar; Kendall H Lee
Journal:  Clin Transl Sci       Date:  2013-04-19       Impact factor: 4.689

Review 6.  How is electrical stimulation of the brain experienced, and how can we tell? Selected considerations on sensorimotor function and speech.

Authors:  Kevin A Mazurek; Marc H Schieber
Journal:  Cogn Neuropsychol       Date:  2019-05-10       Impact factor: 2.468

Review 7.  Cortical hierarchy, dual counterstream architecture and the importance of top-down generative networks.

Authors:  Julien Vezoli; Loïc Magrou; Rainer Goebel; Xiao-Jing Wang; Kenneth Knoblauch; Martin Vinck; Henry Kennedy
Journal:  Neuroimage       Date:  2020-10-21       Impact factor: 6.556

8.  Neurobiology, Functions, and Relevance of Excitatory Amino Acid Transporters (EAATs) to Treatment of Refractory Epilepsy.

Authors:  Aleksey V Zaitsev; Ilya V Smolensky; Pascal Jorratt; Saak V Ovsepian
Journal:  CNS Drugs       Date:  2020-11       Impact factor: 5.749

9.  A model for focal seizure onset, propagation, evolution, and progression.

Authors:  Jyun-You Liou; Elliot H Smith; Lisa M Bateman; Samuel L Bruce; Guy M McKhann; Robert R Goodman; Ronald G Emerson; Catherine A Schevon; L F Abbott
Journal:  Elife       Date:  2020-03-23       Impact factor: 8.140

10.  α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Plasticity Sustains Severe, Fatal Status Epilepticus.

Authors:  Nadia Adotevi; Ewa Lewczuk; Huayu Sun; Suchitra Joshi; Natalia Dabrowska; Sarah Shan; John Williamson; Jaideep Kapur
Journal:  Ann Neurol       Date:  2019-11-20       Impact factor: 10.422

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