Literature DB >> 21903321

Nuclear receptor mRNA expression by HBV in human hepatoblastoma cell lines.

Shuang Wu1, Tatsuo Kanda, Fumio Imazeki, Shingo Nakamoto, Hiroshi Shirasawa, Osamu Yokosuka.   

Abstract

Recent studies have implicated nuclear receptors (NRs) in the development of hepatocarcinogenesis. We assumed that hepatitis B virus (HBV) alters the expression of NRs and coregulators, and compared the gene expression profiling for 84 NRs and related genes between HpeG2.2.15, which secretes complete HBV virion, and HepG2 by real-time RT-PCR with SyBr green. Forty (47.6%) genes were upregulated 2-fold or greater, and only 5 (5.9%) were downregulated 2-fold or more, in HepG2.2.15 compared to HepG2. These results suggest that HBV affects NRs and their related signal transduction, and that they play important roles in viral replication and HBV-related hepatocarcinogenesis.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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Year:  2011        PMID： 21903321     DOI： 10.1016/j.canlet.2011.07.025

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  5 in total

Review 1.  Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity.

Authors:  Xia Jiang; Tatsuo Kanda; Shuang Wu; Masato Nakamura; Tatsuo Miyamura; Shingo Nakamoto; Arup Banerjee; Osamu Yokosuka
Journal:  World J Gastroenterol       Date:  2014-06-21       Impact factor: 5.742

Review 2.  Androgen receptor signaling in hepatocellular carcinoma and pancreatic cancers.

Authors:  Tatsuo Kanda; Xia Jiang; Osamu Yokosuka
Journal:  World J Gastroenterol       Date:  2014-07-28       Impact factor: 5.742

3.  The androgen receptor expression and its activity have different relationships with prognosis in hepatocellular carcinoma.

Authors:  S Acosta-Lopez; D Diaz-Bethencourt; T Concepción-Massip; M C Martin-Fernandez de Basoa; A Plata-Bello; A Gonzalez-Rodriguez; F Perez-Hernandez; J Plata-Bello
Journal:  Sci Rep       Date:  2020-12-16       Impact factor: 4.379

Review 4.  The androgen receptor as an emerging target in hepatocellular carcinoma.

Authors:  Tatsuo Kanda; Osamu Yokosuka
Journal:  J Hepatocell Carcinoma       Date:  2015-06-26

5.  Possible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate Cells.

Authors:  Reina Sasaki; Tatsuo Kanda; Masato Nakamura; Shingo Nakamoto; Yuki Haga; Shuang Wu; Hiroshi Shirasawa; Osamu Yokosuka
Journal:  PLoS One       Date:  2016-01-05       Impact factor: 3.240
  5 in total

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