| Literature DB >> 21903257 |
Irmgard Behlau1, Koushik Mukherjee, Amit Todani, Ann S Tisdale, Fabiano Cade, Liqiang Wang, Elizabeth M Leonard, Fouad R Zakka, Michael S Gilmore, Frederick A Jakobiec, Claes H Dohlman, Alexander M Klibanov.
Abstract
The biocompatibility and antibacterial properties of N,N-hexyl,methyl-polyethylenimine (HMPEI) covalently attached to the Boston Keratoprosthesis (B-KPro) materials was evaluated. By means of confocal and electron microscopies, we observed that HMPEI-derivatized materials exert an inhibitory effect on biofilm formation by Staphylococcus aureus clinical isolates, as compared to the parent poly(methyl methacrylate) (PMMA) and titanium. There was no additional corneal epithelial cell cytotoxicity of HMPEI-coated PMMA compared to that of control PMMA in tissue cultures in vitro. Likewise, no toxicity or adverse reactivity was detected with HMPEI-derivatized PMMA or titanium compared to those of the control materials after intrastromal or anterior chamber implantation in rabbits in vivo.Entities:
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Year: 2011 PMID： 21903257 PMCID： PMC3410931 DOI： 10.1016/j.biomaterials.2011.08.010
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479