OBJECTIVE: The aims of this study were to test the individual association of the serotonin transporter gene (SLC6A4), the brain-derived neurotrophic factor gene (BDNF) and the GABA(A) α(6) receptor subunit gene (GABRA6) with anxiety-related traits and to explore putative gene-gene interactions in a Spanish healthy sample. METHOD: A sample of 937 individuals from the general population completed the Temperament and Character Inventory questionnaire to explore Harm Avoidance (HA) dimension; a subsample of 553 individuals also filled in the Big Five Questionnaire to explore the Neuroticism dimension. The whole sample was genotyped for the 5-HTTLPR polymorphism (SLC6A4 gene), the Val66Met polymorphism (BDNF gene) and the T1521C polymorphism (GABRA6 gene). RESULTS: Homozygous individuals for the T allele of the T1512C polymorphism presented slightly higher scores for HA than C allele carriers (F = 2.96, P = 0.019). In addition, there was a significant gene-gene interaction on HA between the 5-HTTLPR and Val66Met polymorphisms (F = 3.4, P = 0.009). CONCLUSION: GABRA6 emerges as a candidate gene involved in the variability of HA. The effect of a significant gene-gene interaction between the SLC6A4 and BDNF genes on HA could explain part of the genetic basis underlying anxiety-related traits.
OBJECTIVE: The aims of this study were to test the individual association of the serotonin transporter gene (SLC6A4), the brain-derived neurotrophic factor gene (BDNF) and the GABA(A) α(6) receptor subunit gene (GABRA6) with anxiety-related traits and to explore putative gene-gene interactions in a Spanish healthy sample. METHOD: A sample of 937 individuals from the general population completed the Temperament and Character Inventory questionnaire to explore Harm Avoidance (HA) dimension; a subsample of 553 individuals also filled in the Big Five Questionnaire to explore the Neuroticism dimension. The whole sample was genotyped for the 5-HTTLPR polymorphism (SLC6A4 gene), the Val66Met polymorphism (BDNF gene) and the T1521C polymorphism (GABRA6 gene). RESULTS: Homozygous individuals for the T allele of the T1512C polymorphism presented slightly higher scores for HA than C allele carriers (F = 2.96, P = 0.019). In addition, there was a significant gene-gene interaction on HA between the 5-HTTLPR and Val66Met polymorphisms (F = 3.4, P = 0.009). CONCLUSION:GABRA6 emerges as a candidate gene involved in the variability of HA. The effect of a significant gene-gene interaction between the SLC6A4 and BDNF genes on HA could explain part of the genetic basis underlying anxiety-related traits.
Authors: Anne L Ersig; Debra L Schutte; Jennifer Standley; Elizabeth Leslie; Bridget Zimmerman; Charmaine Kleiber; Kirsten Hanrahan; Jeffrey C Murray; Ann Marie McCarthy Journal: Biol Res Nurs Date: 2017-03-13 Impact factor: 2.522
Authors: Patrick M Fisher; Klaus K Holst; Dea Adamsen; Anders Bue Klein; Vibe G Frokjaer; Peter S Jensen; Claus Svarer; Nic Gillings; William F C Baare; Jens D Mikkelsen; Gitte M Knudsen Journal: Hum Brain Mapp Date: 2014-09-13 Impact factor: 5.038
Authors: S Hossein Fatemi; Teri J Reutiman; Timothy D Folsom; Oyvind G Rustan; Robert J Rooney; Paul D Thuras Journal: J Autism Dev Disord Date: 2014-08
Authors: Xenia Gonda; Jane Sarginson; Nora Eszlari; Peter Petschner; Zoltan G Toth; Daniel Baksa; Gabor Hullam; Ian M Anderson; J F William Deakin; Gabriella Juhasz; Gyorgy Bagdy Journal: Sci Rep Date: 2017-10-10 Impact factor: 4.379