| Literature DB >> 21902657 |
Jana Makuc1, Danijel Petrovič.
Abstract
A genetic component of diabetes and its complications (including diabetic nephropathy (DN)) is obvious, but the causative genes and mechanisms have not yet been satisfactorily identified. Oxidative stress is a single mechanism relating all major pathways responsible for diabetic damage. Numerous oxidative stress-related genes are positional candidates (determined by GWAS) and candidate genes studies confirm the association of their polymorphisms with DN. We present here their overview and connection to the "new antioxidant" therapy principle.Entities:
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Year: 2011 PMID: 21902657 DOI: 10.2174/187152511798120949
Source DB: PubMed Journal: Cardiovasc Hematol Agents Med Chem ISSN: 1871-5257