Literature DB >> 21902590

Diversity of HIV type 1 envelope (V3-V5) sequence in HIV type 1-infected Indian children.

Somi Sankaran Prakash1, Rajesh Kalra, Rakesh Lodha, Sushil K Kabra, Kalpana Luthra.   

Abstract

Abstract We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. This virus also had a longer V3 sequence with 37 amino acids, a GRGQ motif, and a methionine residue before it (AIIMS_307). A unique finding was the complete deletion of the V4 region of another virus (AIIMS_363). High sequence diversity was observed in the envelope of the HIV-1-infected Indian children.

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Year:  2011        PMID： 21902590      PMCID： PMC3332366          DOI： 10.1089/AID.2011.0206

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  15 in total

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Journal:  AIDS Res Ther       Date:  2009-12-03       Impact factor: 2.250
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2.  Detecting Selection in the HIV-1 Genome during Sexual Transmission Events.

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