| Literature DB >> 21902588 |
Oon Tek Ng1, Lindsay M Eyzaguirre, Jean K Carr, Kuan Kiat Chew, Li Lin, Arlene Chua, Yee Sin Leo, Andrew D Redd, Thomas C Quinn, Oliver Laeyendecker.
Abstract
A recent HIV-1 molecular epidemiology survey in Singapore identified a novel CRF01_AE/B recombinant form, which accounted for 13 (11.9%) of 109 patient samples. Peripheral blood mononuclear cell DNA from three of these 13 patients was used to generate near full-length sequences to characterize the novel CRF01_AE/B recombinant form. The three isolates had a recombinant structure composed of CRF01_AE and subtype B, and shared identical breakpoints. As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51_01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore.Entities:
Mesh:
Year: 2011 PMID: 21902588 PMCID: PMC3332370 DOI: 10.1089/aid.2011.0177
Source DB: PubMed Journal: AIDS Res Hum Retroviruses ISSN: 0889-2229 Impact factor: 2.205