| Literature DB >> 21902175 |
Federica Pollastro1, Orazio Taglialatela-Scafati, Marco Allarà, Eduardo Muñoz, Vincenzo Di Marzo, Luciano De Petrocellis, Giovani Appendino.
Abstract
The waxy fraction from the variety Carma of fiber hemp (Cannabis sativa) afforded the unusual cannabinoid 4, identified as the farnesyl prenylogue of cannabigerol (CBG, 1) on the basis of its spectroscopic properties. A comparative study of the profile of 4 and 1 toward metabotropic (CB1, CB2) and ionotropic (TRPV1, TRPV2, TRPM8, TRPA1) targets of phytocannabinoids showed that prenylogation increased potency toward CB2 by ca. 5-fold, with no substantial difference toward the other end-points, except for a decreased affinity for TRPM8. The isolation of 4 suggests that C. sativa could contain yet-to-be-discovered prenylogous versions of medicinally relevant cannabinoids, for which their biological profiles could offer interesting opportunities for biomedical exploitation.Entities:
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Year: 2011 PMID： 21902175 DOI： 10.1021/np200500p
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050