| Literature DB >> 21901624 |
Xiangshan Zhao1, Channabasavaiah Basavaraju Gurumurthy, Gautam Malhotra, Sameer Mirza, Shakur Mohibi, Aditya Bele, Meghan G Quinn, Hamid Band, Vimla Band.
Abstract
Recent molecular profiling has identified six major subtypes of breast cancers that exhibit different survival outcomes for patients. To address the origin of different subtypes of breast cancers, we have now identified, isolated, and immortalized (using hTERT) mammary stem/progenitor cells which maintain their stem/progenitor properties even after immortalization. Our decade long research has shown that these stem/progenitor cells are highly susceptible to oncogenesis. Given the emerging evidence that stem/progenitor cells are precursors of cancers and that distinct subtypes of breast cancer have different survival outcome, these cellular models provide novel tools to understand the oncogenic process leading to various subtypes of breast cancers and for future development of novel therapeutic strategies to treat different subtypes of breast cancers.Entities:
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Year: 2011 PMID： 21901624 PMCID： PMC3902662 DOI： 10.1007/978-1-4614-0254-1_11
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622