Nicole Betenia1, Sadie Costello, Ellen A Eisen. 1. Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA 94720-7360, USA.
Abstract
OBJECTIVES: Cervical cancer is caused by human papilloma virus (HPV). However, only a small proportion of women infected with HPV, progress to cervical cancer. Other co-factors must therefore be necessary to cause cervical cancer. We examined cervical cancer in relation to occupational exposure to metalworking fluids (MWF), which are complex mixtures containing several known carcinogens. METHODS: A cohort of 4374 female autoworkers was followed from 1985-2004 for cancer diagnosis. Based on standardized incidence rates (SIR), we focused on cervical cancer in an internal analysis. Pooled logistic regression was used to model the relationship between exposure to three different types of MWF, selected constituents, and incidence of cervical cancer. RESULTS: Based on 40 cases, SIR were statistically significantly elevated for both race specific subgroups: 3.30 and 2.43, respectively for Caucasian and black women. The standard mortality ratio (SMR) was also statistically significantly elevated for Caucasian women (3.44) based on seven observed deaths. There was no association with oil-based straight fluid. Relative risks for soluble and synthetic MWF and nitrosamines were modestly elevated but not statistically significant. CONCLUSIONS: Water-based MWF may play a role in the etiology of cervical cancer. Further studies in larger cohorts of women are needed to clearly establish this relationship.
OBJECTIVES:Cervical cancer is caused by human papilloma virus (HPV). However, only a small proportion of women infected with HPV, progress to cervical cancer. Other co-factors must therefore be necessary to cause cervical cancer. We examined cervical cancer in relation to occupational exposure to metalworking fluids (MWF), which are complex mixtures containing several known carcinogens. METHODS: A cohort of 4374 female autoworkers was followed from 1985-2004 for cancer diagnosis. Based on standardized incidence rates (SIR), we focused on cervical cancer in an internal analysis. Pooled logistic regression was used to model the relationship between exposure to three different types of MWF, selected constituents, and incidence of cervical cancer. RESULTS: Based on 40 cases, SIR were statistically significantly elevated for both race specific subgroups: 3.30 and 2.43, respectively for Caucasian and black women. The standard mortality ratio (SMR) was also statistically significantly elevated for Caucasian women (3.44) based on seven observed deaths. There was no association with oil-based straight fluid. Relative risks for soluble and synthetic MWF and nitrosamines were modestly elevated but not statistically significant. CONCLUSIONS:Water-based MWF may play a role in the etiology of cervical cancer. Further studies in larger cohorts of women are needed to clearly establish this relationship.
Authors: Arthur Brito-Marcelino; Rodrigo Japur Duarte-Tavares; Katienne Brito Marcelino; Julio Alves Silva-Neto Journal: Rev Bras Med Trab Date: 2020-08-04
Authors: Miriam Siegel; Carissa M Rocheleau; Candice Y Johnson; Martha A Waters; Christina C Lawson; Tiffany Riehle-Colarusso; Jennita Reefhuis Journal: Int J Environ Res Public Health Date: 2019-05-04 Impact factor: 3.390
Authors: Sadie Costello; Kevin Chen; Sally Picciotto; Liza Lutzker; Ellen Eisen Journal: Scand J Work Environ Health Date: 2020-05-14 Impact factor: 5.024