| Literature DB >> 21899945 |
Peggy Benad1, Martina Rauner, Tilman D Rachner, Lorenz C Hofbauer.
Abstract
The Wnt signaling pathway is activated in over 50% of women with breast cancer and contributes to tumor progression. Here, we investigated the effects of RU-486 on Wnt signaling in breast cancer cell lines. RU-486 reduced viability of the progesterone receptor-positive MCF-7 and T-47D cells, but had no effect on the triple-negative MDA-MB-231 cells. Furthermore, RU-486 suppressed WNT1 expression of MCF-7 cells by 99%. The addition of recombinant WNT1 partially reversed the RU-486-dependent inhibition of viability in MCF-7, but not in T-47D cells. In conclusion, we identified WNT1 as a novel mediator of the anti-tumor effects of RU-486 in MCF-7 cells.Entities:
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Year: 2011 PMID： 21899945 DOI： 10.1016/j.canlet.2011.08.006
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679