OBJECTIVE: To evaluate whether the size of acute myocardial infarction (AMI) shows circadian variability. DESIGN: An observational, prospective study. SETTING: A 12-bed coronary care unit. PATIENTS: Consecutive patients diagnosed with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. INTERVENTIONS: The patients were divided into two groups according to the time of onset of AMI symptoms (Group A: 0-12hours, Group B: 12-24hours). MAIN VARIABLES OF INTEREST: Age, sex, cardiovascular risk factors, coronary anatomy, left ventricular ejection fraction, infarct location, time from onset of symptoms to reperfusion, presence of heart failure upon admission, and peak troponin I value. RESULTS: A total of 108 patients with a diagnosis of STEMI were included. Patients in group A showed a higher troponin I concentration compared to group B (troponin I: 70.85±16.38 versus 60.90±22.92ng / ml, p=0.003). In the multivariate analysis the onset of AMI between 0-12hours was identified as an independent predictor of infarct size (OR: 1.133, 95%CI 1.012-1.267, p=0.01). CONCLUSIONS: An onset of AMI between 0-12hours results in a significantly larger final size of necrosis compared with any other time of presentation.
OBJECTIVE: To evaluate whether the size of acute myocardial infarction (AMI) shows circadian variability. DESIGN: An observational, prospective study. SETTING: A 12-bed coronary care unit. PATIENTS: Consecutive patients diagnosed with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. INTERVENTIONS: The patients were divided into two groups according to the time of onset of AMI symptoms (Group A: 0-12hours, Group B: 12-24hours). MAIN VARIABLES OF INTEREST: Age, sex, cardiovascular risk factors, coronary anatomy, left ventricular ejection fraction, infarct location, time from onset of symptoms to reperfusion, presence of heart failure upon admission, and peak troponin I value. RESULTS: A total of 108 patients with a diagnosis of STEMI were included. Patients in group A showed a higher troponin I concentration compared to group B (troponin I: 70.85±16.38 versus 60.90±22.92ng / ml, p=0.003). In the multivariate analysis the onset of AMI between 0-12hours was identified as an independent predictor of infarct size (OR: 1.133, 95%CI 1.012-1.267, p=0.01). CONCLUSIONS: An onset of AMI between 0-12hours results in a significantly larger final size of necrosis compared with any other time of presentation.
Authors: Aoife B Kilgallen; Frederieke van den Akker; Dries A M Feyen; Sandra Crnko; Christian J B Snijders Blok; Hendrik Gremmels; Bastiaan C du Pré; Robin Reijers; Pieter A Doevendans; Saskia C A de Jager; Joost P G Sluijter; Vasco Sampaio-Pinto; Linda W van Laake Journal: Front Pharmacol Date: 2022-05-25 Impact factor: 5.988
Authors: Heerajnarain Bulluck; Jennifer Nicholas; Gabriele Crimi; Steven K White; Andrew J Ludman; Silvia Pica; Claudia Raineri; Hector A Cabrera-Fuentes; Derek Yellon; Jose Rodriguez-Palomares; David Garcia-Dorado; Derek J Hausenloy Journal: Int J Cardiol Date: 2016-12-19 Impact factor: 4.164
Authors: Bastiaan du Pré; Toon Van Veen; Sandra Crnko; Marc Vos; Janine Deddens; Pieter Doevendans; Linda Van Laake Journal: Int J Mol Sci Date: 2017-08-01 Impact factor: 5.923