Dorothea Kaufmann1, Anudeep Kaur Dogra, Michael Wink. 1. Institute of Pharmacy and Molecular Biotechnology, Department of Biology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany. dorothea.kaufmann@web.de
Abstract
OBJECTIVES: Inhibition of acetylcholinesterase (AChE) is a common treatment for early stages of the most general form of dementia, Alzheimer's disease. In this study selected components of essential oils, which carry a variety of important functional groups, were tested for their in-vitro anti-acetylcholinesterase activity. METHODS: In-vitro anti-acetylcholinesterase activity was measured by an adapted version of Ellman's colorimetric assay. KEY FINDINGS: 1,8-cineole, carvacrol, myrtenal and verbenone apparently inhibited AChE; the highest inhibitory activity was observed for myrtenal (IC50 = 0.17 mm). This is the first study showing the AChE inhibitory activity of myrtenal. CONCLUSIONS: Our investigations provided evidence for the efficacy of monoterpenes as inhibitors of AChE.
OBJECTIVES: Inhibition of acetylcholinesterase (AChE) is a common treatment for early stages of the most general form of dementia, Alzheimer's disease. In this study selected components of essential oils, which carry a variety of important functional groups, were tested for their in-vitro anti-acetylcholinesterase activity. METHODS: In-vitro anti-acetylcholinesterase activity was measured by an adapted version of Ellman's colorimetric assay. KEY FINDINGS:1,8-cineole, carvacrol, myrtenal and verbenone apparently inhibited AChE; the highest inhibitory activity was observed for myrtenal (IC50 = 0.17 mm). This is the first study showing the AChE inhibitory activity of myrtenal. CONCLUSIONS: Our investigations provided evidence for the efficacy of monoterpenes as inhibitors of AChE.
Authors: Odette Concepción; Julio Belmar; Alexander F de la Torre; Francisco M Muñiz; Mariano W Pertino; Barbara Alarcón; Valeska Ormazabal; Estefania Nova-Lamperti; Felipe A Zúñiga; Claudio A Jiménez Journal: Molecules Date: 2020-04-21 Impact factor: 4.411