Literature DB >> 2189947

Natural products as a source of potential cancer chemotherapeutic and chemopreventive agents.

J M Cassady1, W M Baird, C J Chang.   

Abstract

Recent advances in the chemistry of novel bioactive natural products are reported. This research is directed to the exploration of plants with confirmed activity in bioassays designed to detect potential cancer chemotherapeutic and chemopreventive agents. Structural work and chemical studies are reported for several cytotoxic agents from the plants Annona densicoma, Annona reticulata, Claopodium crispifolium, Polytrichum obioense, and Psorospermum febrifugum. Studies are also reported based on development of a mammalian cell culture benzo[a]pyrene metabolism assay for the detection of potential anticarcinogenic agents from natural products. In this study a number of isoflavonoids and flavonoids with antimutagenic activity have been discovered.

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Year:  1990        PMID： 2189947     DOI： 10.1021/np50067a003

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  19 in total

1.  Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites.

Authors:  Y Kwok; Q Zeng; L H Hurley
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

2.  N-Benzylation of 6-aminoflavone by reductive amination and efficient access to some novel anticancer agents via topoisomerase II inhibition.

Authors:  Nitin M Thorat; Aniket P Sarkate; Deepak K Lokwani; Shailee V Tiwari; Rajaram Azad; Shankar R Thopate
Journal:  Mol Divers       Date:  2020-04-05       Impact factor: 2.943

3.  Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats.

Authors:  Subramaniyan Jayakumar; Arumugam Madankumar; Selvamani Asokkumar; Subramanian Raghunandhakumar; Krishnan Gokula dhas; Sattu Kamaraj; Michael Georget Josephine Divya; Thiruvengadam Devaki
Journal:  Mol Cell Biochem       Date:  2011-08-31       Impact factor: 3.396

Review 4.  RNA targeting by small molecules: Binding of protoberberine, benzophenanthridine and aristolochia alkaloids to various RNA structures.

Authors:  Gopinatha Suresh Kumar
Journal:  J Biosci       Date:  2012-07       Impact factor: 1.826

5.  Psorospermin structural requirements for P-glycoprotein resistance reversal.

Authors:  Steven S Carey; Mary Gleason-Guzman; Vijay Gokhale; Laurence H Hurley
Journal:  Mol Cancer Ther       Date:  2008-11       Impact factor: 6.261

Review 6.  Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?

Authors:  Eva F DeRango-Adem; Jonathan Blay
Journal:  Front Pharmacol       Date:  2021-05-18       Impact factor: 5.810

7.  Targeting RNA by small molecules: comparative structural and thermodynamic aspects of aristololactam-β-D-glucoside and daunomycin binding to tRNA(phe).

Authors:  Abhi Das; Kakali Bhadra; Gopinatha Suresh Kumar
Journal:  PLoS One       Date:  2011-08-16       Impact factor: 3.240

8.  Cytotoxic essential oil from Annona sengalensis Pers. leaves.

Authors:  A L Ahmed; S E M Bassem; Y H Mohamed; M W Gamila
Journal:  Pharmacognosy Res       Date:  2010-07

9.  New potential instrument to fight hepatocellular cancer by restoring p53.

Authors:  Franklin C Vincent; Marek J Los
Journal:  Hepat Mon       Date:  2011-05       Impact factor: 0.660

10.  Tamarix articulata Inhibits Cell Proliferation, Promotes Cell Death Mechanisms and Triggers G0/G1 Cell Cycle Arrest in Hepatocellular Carcinoma Cells.

Authors:  Abdullah M Alnuqaydan; Bilal Rah
Journal:  Food Technol Biotechnol       Date:  2021-06       Impact factor: 3.918
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