Literature DB >> 21898616

Facing the gem-dialkyl effect in enzyme inhibitor design: preparation of homocycloleucine-based azadipeptide nitriles.

Maxim Frizler1, Friederike Lohr, Michael Lülsdorff, Michael Gütschow.   

Abstract

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Year:  2011        PMID： 21898616     DOI： 10.1002/chem.201101350

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


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  9 in total

1.  3-Cyano-3-aza-β-amino Acid Derivatives as Inhibitors of Human Cysteine Cathepsins.

Authors:  Janina Schmitz; Anna-Madeleine Beckmann; Adela Dudic; Tianwei Li; Robert Sellier; Ulrike Bartz; Michael Gütschow
Journal:  ACS Med Chem Lett       Date:  2014-08-11       Impact factor: 4.345

2.  Cathepsin B Inhibitors: Combining Dipeptide Nitriles with an Occluding Loop Recognition Element by Click Chemistry.

Authors:  Janina Schmitz; Tianwei Li; Ulrike Bartz; Michael Gütschow
Journal:  ACS Med Chem Lett       Date:  2015-12-28       Impact factor: 4.345

3.  A BODIPY-Tagged Phosphono Peptide as Activity-Based Probe for Human Leukocyte Elastase.

Authors:  Anna-Christina Schulz-Fincke; Michael Blaut; Annett Braune; Michael Gütschow
Journal:  ACS Med Chem Lett       Date:  2018-03-04       Impact factor: 4.345

4.  Azanitrile Cathepsin K Inhibitors: Effects on Cell Toxicity, Osteoblast-Induced Mineralization and Osteoclast-Mediated Bone Resorption.

Authors:  Zhong-Yuan Ren; Irma Machuca-Gayet; Chantal Domenget; Rene Buchet; Yuqing Wu; Pierre Jurdic; Saida Mebarek
Journal:  PLoS One       Date:  2015-07-13       Impact factor: 3.240

5.  Convergent Synthesis of Two Fluorescent Ebselen-Coumarin Heterodimers.

Authors:  Jim Küppers; Anna Christina Schulz-Fincke; Jerzy Palus; Mirosław Giurg; Jacek Skarżewski; Michael Gütschow
Journal:  Pharmaceuticals (Basel)       Date:  2016-07-08

6.  Addition of 2-(ethylamino)acetonitrile group to nitroxoline results in significantly improved anti-tumor activity in vitro and in vivo.

Authors:  Ana Mitrović; Izidor Sosič; Špela Kos; Urša Lampreht Tratar; Barbara Breznik; Simona Kranjc; Bojana Mirković; Stanislav Gobec; Tamara Lah; Gregor Serša; Janko Kos
Journal:  Oncotarget       Date:  2017-07-17

7.  Mapping the S1 and S1' subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents.

Authors:  Lorenzo Cianni; Carina Lemke; Erik Gilberg; Christian Feldmann; Fabiana Rosini; Fernanda Dos Reis Rocho; Jean F R Ribeiro; Daiane Y Tezuka; Carla D Lopes; Sérgio de Albuquerque; Jürgen Bajorath; Stefan Laufer; Andrei Leitão; Michael Gütschow; Carlos A Montanari
Journal:  PLoS Negl Trop Dis       Date:  2020-03-12

8.  Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity.

Authors:  Adéla Jílková; Martin Horn; Jindřich Fanfrlík; Jim Küppers; Petr Pachl; Pavlína Řezáčová; Martin Lepšík; Pavla Fajtová; Petra Rubešová; Marta Chanová; Conor R Caffrey; Michael Gütschow; Michael Mareš
Journal:  ACS Infect Dis       Date:  2020-12-10       Impact factor: 5.084

9.  Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors.

Authors:  Julian Breidenbach; Carina Lemke; Thanigaimalai Pillaiyar; Laura Schäkel; Ghazl Al Hamwi; Miriam Diett; Robin Gedschold; Nina Geiger; Vittoria Lopez; Salahuddin Mirza; Vigneshwaran Namasivayam; Anke C Schiedel; Katharina Sylvester; Dominik Thimm; Christin Vielmuth; Lan Phuong Vu; Maria Zyulina; Jochen Bodem; Michael Gütschow; Christa E Müller
Journal:  Angew Chem Int Ed Engl       Date:  2021-03-24       Impact factor: 16.823
  9 in total

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