Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Effect of aging on islet beta-cell function and its mechanisms in Wistar rats.

Literature DB >> 21898034

Effect of aging on islet beta-cell function and its mechanisms in Wistar rats.

Zhaoyan Gu¹, Yingzhen Du, Yu Liu, Lichao Ma, Lin Li, Yanping Gong, Hui Tian, Chunlin Li.

Abstract

Type 2 diabetes mellitus is characterized by islet β-cell dysfunction and its incidence increases with age. However, the mechanisms underlying the effect of aging on islet β-cell function are not fully understood. We characterized β-cell function in 4-month-old (young), 14-month-old (adult), and 24-month-old (old) male Wistar rats, and found that islet β-cell function decreased gradually with age. Old rats displayed oral glucose intolerance and exhibited a decrease in glucose-stimulated insulin release (GSIR) and palmitic acid-stimulated insulin release (PSIR). Furthermore, total superoxide dismutase (T-SOD), CuZn superoxide dismutase (CuZn-SOD), and glutathione peroxidase (GSH-Px) activity decreased, whereas serum malondialdehyde (MDA) levels increased in the older rats. Moreover, we detected a significant reduction in β-cell proliferation and an increase in the frequency of apoptotic β-cells in the islets of rats in the old group. Finally, Anxa1 expression in the islets of old rats was significantly upregulated. These data provide new insights into the development of age-related β-cell dysfunction in rats.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2011 PMID： 21898034 PMCID： PMC3528366 DOI： 10.1007/s11357-011-9312-7

Source DB: PubMed Journal: Age (Dordr) ISSN： 0161-9152

39 in total

1. Natural history of a proinsulin-secreting insulinoma: from symptomatic hypoglycemia to clinical diabetes.

Authors: E Arioglu; N A Gottlieb; C A Koch; J L Doppman; N J Grey; P Gorden
Journal: J Clin Endocrinol Metab Date: 2000-10 Impact factor: 5.958

Review 2. Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?

Authors: A J Scheen
Journal: Diabetes Metab Date: 2005-12 Impact factor: 6.041

3. Study of the prevalence of diabetes mellitus in adults in the Shougang Corporation in Beijing.

Authors: C Y Pan; J M Lu; H Tian; X T Kong; X P Lu; C Yao; C E Jiang; X X Deng; S Y Wang; X L Zhang; Z S Wang; L Cui
Journal: Diabet Med Date: 1996-07 Impact factor: 4.359

4. A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation.

Authors: S Henis-Korenblit; N L Strumpf; D Goldstaub; A Kimchi
Journal: Mol Cell Biol Date: 2000-01 Impact factor: 4.272

5. Effect of donor age on function of isolated human islets.

Authors: Sung-Hee Ihm; Ippei Matsumoto; Toshiya Sawada; Masahiko Nakano; Hui J Zhang; Jeffrey D Ansite; David E R Sutherland; Bernhard J Hering
Journal: Diabetes Date: 2006-05 Impact factor: 9.461

6. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994.

Authors: M I Harris; K M Flegal; C C Cowie; M S Eberhardt; D E Goldstein; R R Little; H M Wiedmeyer; D D Byrd-Holt
Journal: Diabetes Care Date: 1998-04 Impact factor: 19.112

Review 7. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases.

Authors: Y Lavrovsky; B Chatterjee; R A Clark; A K Roy
Journal: Exp Gerontol Date: 2000-08 Impact factor: 4.032

8. K-value and low insulin secretion in a non-obese white population: predicted glucose tolerance after 25 years.

Authors: M Alvarsson; A Wajngot; E Cerasi; S Efendic
Journal: Diabetologia Date: 2005-09-14 Impact factor: 10.122

9. Very slow turnover of beta-cells in aged adult mice.

Authors: Monica Teta; Simon Y Long; Lynn M Wartschow; Matthew M Rankin; Jake A Kushner
Journal: Diabetes Date: 2005-09 Impact factor: 9.461

10. American Diabetes Association diabetes diagnostic criteria, advancing age, and cardiovascular disease risk profiles: results from the Third National Health and Nutrition Examination Survey.

Authors: H E Resnick; M I Harris; D B Brock; T B Harris
Journal: Diabetes Care Date: 2000-02 Impact factor: 19.112

16 in total

1. A persistent increase in insulin-stimulated glucose uptake by both fast-twitch and slow-twitch skeletal muscles after a single exercise session by old rats.

Authors: Yuanyuan Xiao; Naveen Sharma; Edward B Arias; Carlos M Castorena; Gregory D Cartee
Journal: Age (Dordr) Date: 2013-06

2. Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis.

Authors: Jeremy A Lavine; Carly R Kibbe; Mieke Baan; Sirinart Sirinvaravong; Heidi M Umhoefer; Kimberly A Engler; Louise M Meske; Kaitlyn A Sacotte; Daniel P Erhardt; Dawn Belt Davis
Journal: Am J Physiol Endocrinol Metab Date: 2015-09-22 Impact factor: 4.310

Effect of aging on islet beta-cell function and its mechanisms in Wistar rats.

1. Natural history of a proinsulin-secreting insulinoma: from symptomatic hypoglycemia to clinical diabetes.

Review 2. Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?

3. Study of the prevalence of diabetes mellitus in adults in the Shougang Corporation in Beijing.

4. A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation.

5. Effect of donor age on function of isolated human islets.

6. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994.

Review 7. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases.

8. K-value and low insulin secretion in a non-obese white population: predicted glucose tolerance after 25 years.

9. Very slow turnover of beta-cells in aged adult mice.

10. American Diabetes Association diabetes diagnostic criteria, advancing age, and cardiovascular disease risk profiles: results from the Third National Health and Nutrition Examination Survey.

1. A persistent increase in insulin-stimulated glucose uptake by both fast-twitch and slow-twitch skeletal muscles after a single exercise session by old rats.

2. Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis.

3. Young capillary vessels rejuvenate aged pancreatic islets.

4. Impaired autophagic function in rat islets with aging.

5. Obesity improves myocardial ischaemic tolerance and RISK signalling in insulin-insensitive rats.

6. Pancreatic function, type 2 diabetes, and metabolism in aging.

7. Isolated pancreatic islet yield and quality is inversely related to organ donor age in rats.

8. Steroidogenic Factor 1 in the Ventromedial Nucleus of the Hypothalamus Regulates Age-Dependent Obesity.

9. Increase of Calcium Sensing Receptor Expression Is Related to Compensatory Insulin Secretion during Aging in Mice.

10. Age-related oxidative changes in pancreatic islets are predominantly located in the vascular system.