Sir,I read an article entitled “Heparin-induced thrombocytopenia (HIT) – Type 2”[1] with interest. I would like to congratulate author for his effort to concise such a topic in a nice manner. However, I would like to add few more information regarding this entity which you may find useful [Table 1].
Table 1
Features of HIT
Features of HITPretest probability is calculated on the basis of 4Ts: Thrombocytopenia, timing of thrombocytopenia, thrombosis, other cause of thrombocytopenia. Probability is high if more than 50% drop in platelet count after 5 days of initiation of heparin and new development of thrombosis with no other cause for thrombocytopenia.I would like to summarize the treatment for HIT: Stop heparin, postpone warfarin until substantial recovery in platelet count, avoid platelet transfusions,[3] start alternative anticoagulants like lepirudin and argatroban (direct thrombin inhibitor), danaparoid, or fondaparinux (factor Xa inhibitor).Fondaparinux is a synthetic heparin pentasaccharide which does not cross-react with HIT antibodies and can be used for the treatment of HIT.[4]