| Literature DB >> 21897012 |
Xinyuan Huang1, Yanying Zhao, Shaohui Jia, Dongjing Yan, Zhengwang Chen.
Abstract
We investigated the effects of daintain/AIF-1, a novel inflammatory cytokine, on INS-1β cells. Cells incubated with daintain/AIF-1 showed decreased cell viability and glucose-stimulated insulin secretion, as well as upregulated apoptosis and NO production. These deleterious effects of daintain/AIF-1 indicate that daintain/AIF-1 plays important roles in the dysfunction of pancreatic β cells in type-1 diabetes.Entities:
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Year: 2011 PMID： 21897012 DOI： 10.1271/bbb.110317
Source DB: PubMed Journal: Biosci Biotechnol Biochem ISSN： 0916-8451 Impact factor: 2.043