Literature DB >> 21896275

The tumor suppressor p33ING1b upregulates p16INK4a expression and induces cellular senescence.

Na Li1, Qian Li, Xiaoxiao Cao, Ganye Zhao, Lixiang Xue, Tanjun Tong.   

Abstract

ING1 protein is a tumor suppressor which plays significant roles in multiple cellular activities. p47(ING1a) and p33(ING1b) are major splice isoforms of ING1 and their roles in senescence need further investigations. Here we studied the functions of ING1 isoforms in cellular senescence and gene regulation, with focus on p16(INK4a). We observe that p33(ING1b) protein is the major ING1 isoform expressed in 2BS human diploid fibroblasts. Overexpression of p33(ING1b) induces cellular senescence and upregulates p16(INK4a) expression in 2BS fibroblasts. p33(ING1b) upregulates p16(INK4a) transcription. p33(ING1b) and p300 bind to the p16(INK4a) promoter. p300/CBP-specific inhibitor curcumin can reverse the induction of p16(INK4a) by p33(ING1b). These results help to better understand the function of ING1.
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21896275     DOI： 10.1016/j.febslet.2011.08.044

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  16 in total

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Authors:  Adana A Llanos; Ramona G Dumitrescu; Theodore M Brasky; Zhenhua Liu; Joel B Mason; Catalin Marian; Kepher H Makambi; Scott L Spear; Bhaskar V S Kallakury; Jo L Freudenheim; Peter G Shields
Journal:  Carcinogenesis       Date:  2014-10-24       Impact factor: 4.944

Review 2.  ING1 and ING2: multifaceted tumor suppressor genes.

Authors:  Claire Guérillon; Delphine Larrieu; Rémy Pedeux
Journal:  Cell Mol Life Sci       Date:  2013-02-15       Impact factor: 9.261

3.  Ectopic expression of p33ING1b suppresses proliferation and induces apoptosis in colonic adenocarcinoma cells.

Authors:  A I Jia; Yifei Lv; Xueyan Guo; L I Ren; Jie Qin
Journal:  Oncol Lett       Date:  2015-06-17       Impact factor: 2.967

4.  Increased expression of enzymes of triglyceride synthesis is essential for the development of hepatic steatosis.

Authors:  Jingling Jin; Polina Iakova; Meghan Breaux; Emily Sullivan; Nicole Jawanmardi; Dahu Chen; Yanjun Jiang; Estela M Medrano; Nikolai A Timchenko
Journal:  Cell Rep       Date:  2013-03-14       Impact factor: 9.423

Review 5.  Telomeres-structure, function, and regulation.

Authors:  Weisi Lu; Yi Zhang; Dan Liu; Zhou Songyang; Ma Wan
Journal:  Exp Cell Res       Date:  2012-09-21       Impact factor: 3.905

Review 6.  INGs are potential drug targets for cancer.

Authors:  Runyun Zhang; Jianhua Jin; Juanjuan Shi; Yongzhong Hou
Journal:  J Cancer Res Clin Oncol       Date:  2016-08-20       Impact factor: 4.553

7.  SIRT6 delays cellular senescence by promoting p27Kip1 ubiquitin-proteasome degradation.

Authors:  Ganye Zhao; Hui Wang; Chenzhong Xu; Pan Wang; Jun Chen; Pengfeng Wang; Zhaomeng Sun; Yuanyuan Su; Zhao Wang; Limin Han; Tanjun Tong
Journal:  Aging (Albany NY)       Date:  2016-09-16       Impact factor: 5.682

Review 8.  The emerging role of alternative splicing in senescence and aging.

Authors:  Mathieu Deschênes; Benoit Chabot
Journal:  Aging Cell       Date:  2017-07-13       Impact factor: 9.304

9.  The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.

Authors:  Uma Karthika Rajarajacholan; Subhash Thalappilly; Karl Riabowol
Journal:  PLoS Biol       Date:  2013-03-05       Impact factor: 8.029

10.  Stromal ING1 expression induces a secretory phenotype and correlates with breast cancer patient survival.

Authors:  Satbir Thakur; Arash Nabbi; Alexander Klimowicz; Karl Riabowol
Journal:  Mol Cancer       Date:  2015-08-27       Impact factor: 27.401
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