Literature DB >> 21895018

Copper-mediated cyanation of aryl halide with the combined cyanide source.

Guoying Zhang1, Xinyi Ren, Jianbin Chen, Maolin Hu, Jiang Cheng.   

Abstract

A simple copper-mediated cyanation of aryl halide with the combination of ammonium bicarbonate and N,N-dimethylformamide as a cyanide source is achieved, providing nitriles in moderate to good yields. This new approach represents an exceedingly practical and safe method for the synthesis of aryl nitriles.
© 2011 American Chemical Society

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Year:  2011        PMID： 21895018     DOI： 10.1021/ol201713b

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  One-pot regioselective C-H activation iodination-cyanation of 2,4-diarylquinazolines using malononitrile as a cyano source.

Authors:  Ziqiao Yan; Banlai Ouyang; Xunchun Mao; Wei Gao; Zhihong Deng; Yiyuan Peng
Journal:  RSC Adv       Date:  2019-06-11       Impact factor: 4.036

2.  Sea-Island-Like Morphology of CuNi Bimetallic Nanoparticles Uniformly Anchored on Single Layer Graphene Oxide as a Highly Efficient and Noble-Metal-Free Catalyst for Cyanation of Aryl Halides.

Authors:  Gopiraman Mayakrishnan; Vijayakumar Elayappan; Ick Soo Kim; Ill-Min Chung
Journal:  Sci Rep       Date:  2020-01-20       Impact factor: 4.379
  2 in total

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