Literature DB >> 21894238

A simple and efficient route to the FKBP-binding domain from rapamycin.

Wei Li1, Shridhar Bhat, Jun O Liu.   

Abstract

A simple and highly efficient route to the FKBP-binding domain (FKBD) from the natural product rapamycin has been developed, which entails a sequence of ozonolysis/Baeyer-Villiger/Wittig reactions. The newly synthesized FKBD may serve as a core to assemble hybrid macrocyclic libraries for the discovery of novel probes of protein function and to synthesize new ligands for the FKBP family of proteins.

Entities:  

Year:  2011        PMID： 21894238      PMCID： PMC3165043          DOI： 10.1016/j.tetlet.2011.07.094

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  15 in total

1.  Probing immunosuppressant action with a nonnatural immunophilin ligand.

Authors:  B E Bierer; P K Somers; T J Wandless; S J Burakoff; S L Schreiber
Journal:  Science       Date:  1990-10-26       Impact factor: 47.728

2.  Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12.

Authors:  W Shou; B Aghdasi; D L Armstrong; Q Guo; S Bao; M J Charng; L M Mathews; M D Schneider; S L Hamilton; M M Matzuk
Journal:  Nature       Date:  1998-01-29       Impact factor: 49.962

3.  Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.

Authors:  C R Kissinger; H E Parge; D R Knighton; C T Lewis; L A Pelletier; A Tempczyk; V J Kalish; K D Tucker; R E Showalter; E W Moomaw
Journal:  Nature       Date:  1995-12-07       Impact factor: 49.962

4.  FKBP12 binds to acylated H-ras and promotes depalmitoylation.

Authors:  Ian M Ahearn; Frederick D Tsai; Helen Court; Mo Zhou; Benjamin C Jennings; Mahiuddin Ahmed; Nicole Fehrenbacher; Maurine E Linder; Mark R Philips
Journal:  Mol Cell       Date:  2011-01-21       Impact factor: 17.970

5.  Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.

Authors:  J Liu; J D Farmer; W S Lane; J Friedman; I Weissman; S L Schreiber
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582

6.  Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.

Authors:  J Heitman; N R Movva; M N Hall
Journal:  Science       Date:  1991-08-23       Impact factor: 47.728

7.  Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.

Authors:  J Choi; J Chen; S L Schreiber; J Clardy
Journal:  Science       Date:  1996-07-12       Impact factor: 47.728

8.  Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein.

Authors:  A B Brillantes; K Ondrias; A Scott; E Kobrinsky; E Ondriasová; M C Moschella; T Jayaraman; M Landers; B E Ehrlich; A R Marks
Journal:  Cell       Date:  1994-05-20       Impact factor: 41.582

9.  A mammalian protein targeted by G1-arresting rapamycin-receptor complex.

Authors:  E J Brown; M W Albers; T B Shin; K Ichikawa; C T Keith; W S Lane; S L Schreiber
Journal:  Nature       Date:  1994-06-30       Impact factor: 49.962

10.  A putative sirolimus (rapamycin) effector protein.

Authors:  Y Chen; H Chen; A E Rhoad; L Warner; T J Caggiano; A Failli; H Zhang; C L Hsiao; K Nakanishi; K L Molnar-Kimber
Journal:  Biochem Biophys Res Commun       Date:  1994-08-30       Impact factor: 3.575
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  3 in total

1.  PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson's disease.

Authors:  Hyejin Park; Tae-In Kam; Hanjing Peng; Shih-Ching Chou; Amir A Mehrabani-Tabari; Jae-Jin Song; Xiling Yin; Senthilkumar S Karuppagounder; George K Umanah; A V Subba Rao; YuRee Choi; Akanksha Aggarwal; Sohyun Chang; Hyunhee Kim; Jiyoung Byun; Jun O Liu; Ted M Dawson; Valina L Dawson
Journal:  Cell       Date:  2022-05-10       Impact factor: 66.850

2.  Drug Modulators of B Cell Signaling Pathways and Epstein-Barr Virus Lytic Activation.

Authors:  John G Kosowicz; Jaeyeun Lee; Brandon Peiffer; Zufeng Guo; Jianmeng Chen; Gangling Liao; S Diane Hayward; Jun O Liu; Richard F Ambinder
Journal:  J Virol       Date:  2017-07-27       Impact factor: 5.103

3.  Rapamycin-inspired macrocycles with new target specificity.

Authors:  Zufeng Guo; Sam Y Hong; Jingxin Wang; Shahid Rehan; Wukun Liu; Hanjing Peng; Manisha Das; Wei Li; Shridhar Bhat; Brandon Peiffer; Brett R Ullman; Chung-Ming Tse; Zlatina Tarmakova; Cordelia Schiene-Fischer; Gunter Fischer; Imogen Coe; Ville O Paavilainen; Zhaoli Sun; Jun O Liu
Journal:  Nat Chem       Date:  2018-12-10       Impact factor: 24.427
  3 in total

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