| Literature DB >> 21894215 |
Jörg Singer1, Christian A Koch, Woubet Kassahun, Peter Lamesch, Graeme Eisenhofer, Regine Kluge, Thomas Lincke, Matthias Seiwerts, Gudrun Borte, Katrin Schierle, Ralf Paschke.
Abstract
BACKGROUND: A 59-year-old man presented for a follow-up, 6 years after surgery for a large pheochromocytoma. He had suffered from diabetes mellitus, hypertension and abdominal pain in the right flank region. Previous postoperative follow-up did not reveal tumor recurrence. INVESTIGATION: Measurement of plasma free metanephrine and normetanephrine by high-performance liquid chromatography and radioimmunoassay; 123I-metaiodobenzylguanidine (MIBG) scintigraphy; hybrid 123I-MIBG single-photon emission CT (SPECT)-CT; MRI; testing for plasma norepinephrine and epinephrine; intraoperative ultrasonography; histological staining for chromogranin A and synaptophysin; and postoperative 18F-dihydroxyphenylalanine (DOPA) PET scan. DIAGNOSIS: Recurrent pheochromocytoma. MANAGEMENT: Laparotomy with tumor resection. Reduction of antihypertensive medications. Further follow-up by MRI, hybrid 123I-MIBG SPECT-CT and testing for plasma catecholamines and free metanephrines.Entities:
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Year: 2011 PMID： 21894215 DOI： 10.1038/nrendo.2011.132
Source DB: PubMed Journal: Nat Rev Endocrinol ISSN： 1759-5029 Impact factor: 43.330