Literature DB >> 21893161

Morphology of the external genitalia of the adult male and female mice as an endpoint of sex differentiation.

Dana A Weiss1, Esequiel Rodriguez, Tristan Cunha, Julia Menshenina, Dale Barcellos, Lok Yun Chan, Gail Risbridger, Laurence Baskin, Gerald Cunha.   

Abstract

Adult external genitalia (ExG) are the endpoints of normal sex differentiation. Detailed morphometric analysis and comparison of adult mouse ExG has revealed 10 homologous features distinguishing the penis and clitoris that define masculine vs. feminine sex differentiation. These features have enabled the construction of a simple metric to evaluate various intersex conditions in mutant or hormonally manipulated mice. This review focuses on the morphology of the adult mouse penis and clitoris through detailed analysis of histologic sections, scanning electron microscopy, and three-dimensional reconstruction. We also present previous results from evaluation of "non-traditional" mammals, such as the spotted hyena and wallaby to demonstrate the complex process of sex differentiation that involves not only androgen-dependent processes, but also estrogen-dependent and hormone-independent mechanisms. Copyright Â
© 2011 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Mesh：

Year:  2011        PMID： 21893161      PMCID： PMC3717118          DOI： 10.1016/j.mce.2011.08.009

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  45 in total

1.  Embryonic development of mouse external genitalia: insights into a unique mode of organogenesis.

Authors:  Kentaro Suzuki; Yukiko Ogino; Ryutaro Murakami; Yoshihiko Satoh; Daniel Bachiller; Gen Yamada
Journal:  Evol Dev       Date:  2002 Mar-Apr       Impact factor: 1.930

2.  Expression of functional estrogen receptors in human fetal male external genitalia.

Authors:  C Crescioli; M Maggi; G B Vannelli; P Ferruzzi; S Granchi; R Mancina; M Muratori; G Forti; M Serio; M Luconi
Journal:  J Clin Endocrinol Metab       Date:  2003-04       Impact factor: 5.958

3.  New insights on the morphology of adult mouse penis.

Authors:  Esequiel Rodriguez; Dana A Weiss; Jennifer H Yang; Julia Menshenina; Max Ferretti; Tristan J Cunha; Dale Barcellos; Lok Yun Chan; Gail Risbridger; Gerald R Cunha; Laurence S Baskin
Journal:  Biol Reprod       Date:  2011-09-14       Impact factor: 4.285

Review 4.  Hypospadias and urethral development.

Authors:  L S Baskin
Journal:  J Urol       Date:  2000-03       Impact factor: 7.450

5.  Evidence for a potential role of estrogen in the penis: detection of estrogen receptor-alpha and -beta messenger ribonucleic acid and protein.

Authors:  Subrina Jesmin; Chishimba N Mowa; Naoyuki Matsuda; Alaa-Eldin Salah-Eldin; Hiroko Togashi; Ichiro Sakuma; Yuichi Hattori; Akira Kitabatake
Journal:  Endocrinology       Date:  2002-12       Impact factor: 4.736

6.  Sonic hedgehog signaling from the urethral epithelium controls external genital development.

Authors:  Claire L Perriton; Nicola Powles; Chin Chiang; Mark K Maconochie; Martin J Cohn
Journal:  Dev Biol       Date:  2002-07-01       Impact factor: 3.582

7.  Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia development by concerted actions of BMP signaling [corrected].

Authors:  Kentaro Suzuki; Daniel Bachiller; YiPing P Chen; Mami Kamikawa; Hidenao Ogi; Ryama Haraguchi; Yukiko Ogino; Yasuhiro Minami; Yuji Mishina; Kyung Ahn; E Bryan Crenshaw; Gen Yamada
Journal:  Development       Date:  2003-11-05       Impact factor: 6.868

8.  Urogenital system of the spotted hyena (Crocuta crocuta Erxleben): a functional histological study.

Authors:  Gerald R Cunha; Yuzhuo Wang; Ned J Place; Wenhui Liu; Larry Baskin; Stephen E Glickman
Journal:  J Morphol       Date:  2003-05       Impact factor: 1.804

9.  Exposure to naturally circulating androgens during foetal life incurs direct reproductive costs in female spotted hyenas, but is prerequisite for male mating.

Authors:  C M Drea; N J Place; M L Weldele; E M Coscia; P Licht; S E Glickman
Journal:  Proc Biol Sci       Date:  2002-10-07       Impact factor: 5.349

10.  Androgen and estrogen receptors in the human corpus cavernosum penis: immunohistochemical and cell culture results.

Authors:  Dirk Schultheiss; Rafael Badalyan; Adrian Pilatz; Alexander I Gabouev; Norbert Schlote; Jörg Wefer; Reinhard von Wasielewski; Heike Mertsching; Michael Sohn; Christian G Stief; Udo Jonas
Journal:  World J Urol       Date:  2003-10-29       Impact factor: 4.226
View more
  20 in total

1.  New insights on the morphology of adult mouse penis.

Authors:  Esequiel Rodriguez; Dana A Weiss; Jennifer H Yang; Julia Menshenina; Max Ferretti; Tristan J Cunha; Dale Barcellos; Lok Yun Chan; Gail Risbridger; Gerald R Cunha; Laurence S Baskin
Journal:  Biol Reprod       Date:  2011-09-14       Impact factor: 4.285

2.  Prenatal diethylstilbestrol induces malformation of the external genitalia of male and female mice and persistent second-generation developmental abnormalities of the external genitalia in two mouse strains.

Authors:  Phitsanu Mahawong; Adriane Sinclair; Yi Li; Bruce Schlomer; Esequiel Rodriguez; Max M Ferretti; Baomei Liu; Laurence S Baskin; Gerald R Cunha
Journal:  Differentiation       Date:  2014-10-14       Impact factor: 3.880

3.  Renal Subcapsular xenografing of human fetal external genital tissue - A new model for investigating urethral development.

Authors:  Dylan Isaacson; Joel Shen; Mei Cao; Adriane Sinclair; Xuan Yue; Gerald Cunha; Laurence Baskin
Journal:  Differentiation       Date:  2017-09-22       Impact factor: 3.880

4.  Anatomy of mole external genitalia: Setting the record straight.

Authors:  Adriane Watkins Sinclair; Stephen E Glickman; Laurence Baskin; Gerald R Cunha
Journal:  Anat Rec (Hoboken)       Date:  2016-01-30       Impact factor: 2.064

5.  An illustrated anatomical ontology of the developing mouse lower urogenital tract.

Authors:  Kylie M Georgas; Jane Armstrong; Janet R Keast; Christine E Larkins; Kirk M McHugh; E Michelle Southard-Smith; Martin J Cohn; Ekatherina Batourina; Hanbin Dan; Kerry Schneider; Dennis P Buehler; Carrie B Wiese; Jane Brennan; Jamie A Davies; Simon D Harding; Richard A Baldock; Melissa H Little; Chad M Vezina; Cathy Mendelsohn
Journal:  Development       Date:  2015-05-12       Impact factor: 6.868

6.  Comparative effects of neonatal diethylstilbestrol on external genitalia development in adult males of two mouse strains with differential estrogen sensitivity.

Authors:  Phitsanu Mahawong; Adriane Sinclair; Yi Li; Bruce Schlomer; Esequiel Rodriguez; Max M Ferretti; Baomai Liu; Laurence S Baskin; Gerald R Cunha
Journal:  Differentiation       Date:  2014-10-16       Impact factor: 3.880

7.  Sexual differentiation in the male and female mouse from days 0 to 21: a detailed and novel morphometric description.

Authors:  Bruce J Schlomer; Max Feretti; Esequiel Rodriguez; Sarah Blaschko; Gerald Cunha; Laurence Baskin
Journal:  J Urol       Date:  2013-03-07       Impact factor: 7.450

8.  Mouse hypospadias: A critical examination and definition.

Authors:  Adriane Watkins Sinclair; Mei Cao; Joel Shen; Paul Cooke; Gail Risbridger; Laurence Baskin; Gerald R Cunha
Journal:  Differentiation       Date:  2016-04-05       Impact factor: 3.880

9.  Specific morphogenetic events in mouse external genitalia sex differentiation are responsive/dependent upon androgens and/or estrogens.

Authors:  Esequiel Rodriguez; Dana A Weiss; Max Ferretti; Hong Wang; Julia Menshenia; Gail Risbridger; David Handelsman; Gerald Cunha; Laurence Baskin
Journal:  Differentiation       Date:  2012-08-25       Impact factor: 3.880

10.  Dkk1 in the peri-cloaca mesenchyme regulates formation of anorectal and genitourinary tracts.

Authors:  Chaoshe Guo; Ye Sun; Chunming Guo; Bryan T MacDonald; Joseph G Borer; Xue Li
Journal:  Dev Biol       Date:  2014-01-01       Impact factor: 3.582
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.