| Literature DB >> 21892151 |
Andreas Keller1, Petra Leidinger, Andrea Bauer, Abdou Elsharawy, Jan Haas, Christina Backes, Anke Wendschlag, Nathalia Giese, Christine Tjaden, Katja Ott, Jens Werner, Thilo Hackert, Klemens Ruprecht, Hanno Huwer, Junko Huebers, Gunnar Jacobs, Philip Rosenstiel, Henrik Dommisch, Arne Schaefer, Joachim Müller-Quernheim, Bernd Wullich, Bastian Keck, Norbert Graf, Joerg Reichrath, Britta Vogel, Almut Nebel, Sven U Jager, Peer Staehler, Ioannis Amarantos, Valesca Boisguerin, Cord Staehler, Markus Beier, Matthias Scheffler, Markus W Büchler, Joerg Wischhusen, Sebastian F M Haeusler, Johannes Dietl, Sylvia Hofmann, Hans-Peter Lenhof, Stefan Schreiber, Hugo A Katus, Wolfgang Rottbauer, Benjamin Meder, Joerg D Hoheisel, Andre Franke, Eckart Meese.
Abstract
In a multicenter study, we determined the expression profiles of 863 microRNAs by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and validated this 'miRNome' by quantitative real-time PCR. We detected consistently deregulated profiles for all tested diseases; pathway analysis confirmed disease association of the respective microRNAs. We observed significant correlations (P = 0.004) between the genomic location of disease-associated genetic variants and deregulated microRNAs.Entities:
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Year: 2011 PMID： 21892151 DOI： 10.1038/nmeth.1682
Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547