| Literature DB >> 21890220 |
D L Gruol1, A Puro, C Hao, P Blakely, E Janneke, K Vo.
Abstract
IL-6 is an important signaling molecule in the CNS. CNS neurons express IL-6 receptors and their signal transduction molecules, consistent with a role for IL-6 in neuronal physiology. Research indicates that IL-6 levels are low in the normal brain but can be significantly elevated in CNS injury and disease. Relatively little is known about how the elevated levels of IL-6 affect neurons. In the current study we show that under conditions of chronic exposure, IL-6 induces alterations in the level of protein expression in developing CNS cells. Such changes may play a role in the altered CNS function observed in CNS conditions associated with elevated levels of IL-6 in the CNS. Copyright ÂEntities:
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Year: 2011 PMID： 21890220 PMCID： PMC3428218 DOI： 10.1016/j.jneuroim.2011.08.009
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478