OBJECTIVE: We sought to determine whether giving birth preterm is associated with raised maternal C-reactive protein (CRP) in later life and whether the association is specific to indicated or spontaneous delivery. STUDY DESIGN: This was a Scotland-wide retrospective cohort study of 1124 women who had a first pregnancy resulting in a singleton, liveborn infant delivered between 24-43 weeks' gestation. Linear regression analysis was used to examine the association between preterm delivery and subsequent CRP concentration. RESULTS: The difference in CRP between women who delivered term and preterm was nonsignificant on univariate analysis (beta coefficient 0.04, P = .18) but was statistically significant following adjustment for potential confounders (beta coefficient 0.05, P < .05). On subgroup analysis the association was specific to women who had had indicated preterm delivery (unadjusted beta coefficient 0.09, P < .01; adjusted beta coefficient 0.09, P < .01). CONCLUSION: Women who undergo indicated preterm delivery are at increased risk of raised CRP in later life.
OBJECTIVE: We sought to determine whether giving birth preterm is associated with raised maternal C-reactive protein (CRP) in later life and whether the association is specific to indicated or spontaneous delivery. STUDY DESIGN: This was a Scotland-wide retrospective cohort study of 1124 women who had a first pregnancy resulting in a singleton, liveborn infant delivered between 24-43 weeks' gestation. Linear regression analysis was used to examine the association between preterm delivery and subsequent CRP concentration. RESULTS: The difference in CRP between women who delivered term and preterm was nonsignificant on univariate analysis (beta coefficient 0.04, P = .18) but was statistically significant following adjustment for potential confounders (beta coefficient 0.05, P < .05). On subgroup analysis the association was specific to women who had had indicated preterm delivery (unadjusted beta coefficient 0.09, P < .01; adjusted beta coefficient 0.09, P < .01). CONCLUSION:Women who undergo indicated preterm delivery are at increased risk of raised CRP in later life.
Authors: Lauren J Tanz; Jennifer J Stuart; Stacey A Missmer; Eric B Rimm; Jennifer A Sumner; Mary A Vadnais; Janet W Rich-Edwards Journal: Pregnancy Hypertens Date: 2018-04-18 Impact factor: 2.899
Authors: Margo B Minissian; Sarah Kilpatrick; Jo-Ann Eastwood; Wendie A Robbins; Eynav E Accortt; Janet Wei; Chrisandra L Shufelt; Lynn V Doering; C Noel Bairey Merz Journal: Circulation Date: 2018-02-20 Impact factor: 29.690
Authors: Janet M Catov; Andrew D Althouse; Cora E Lewis; Emily W Harville; Erica P Gunderson Journal: Obstet Gynecol Date: 2016-06 Impact factor: 7.623