Literature DB >> 21889591

Gene therapy for amyotrophic lateral sclerosis.

Thais Federici1, Nicholas M Boulis.   

Abstract

Gene therapy continues to be a potential option for amyotrophic lateral sclerosis (ALS). This chapter will inform the reader about promising therapeutic transgenes and proof-of-principle studies in transgenic rodent models of ALS. Challenges regarding the disease targets and time for therapeutic intervention will be also discussed. Finally, restorative therapy for ALS, as well as gene therapy for other motor neuron diseases will be briefly reviewed.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21889591     DOI： 10.1016/j.nbd.2011.08.018

Source DB:  PubMed          Journal:  Neurobiol Dis        ISSN： 0969-9961            Impact factor:   5.996


  5 in total

Review 1.  Challenges of gene delivery to the central nervous system and the growing use of biomaterial vectors.

Authors:  Devan L Puhl; Anthony R D'Amato; Ryan J Gilbert
Journal:  Brain Res Bull       Date:  2019-06-05       Impact factor: 4.077

Review 2.  Antioxidant gene therapy against neuronal cell death.

Authors:  Juliana Navarro-Yepes; Laura Zavala-Flores; Annadurai Anandhan; Fang Wang; Maciej Skotak; Namas Chandra; Ming Li; Aglaia Pappa; Daniel Martinez-Fong; Luz Maria Del Razo; Betzabet Quintanilla-Vega; Rodrigo Franco
Journal:  Pharmacol Ther       Date:  2013-12-12       Impact factor: 12.310

Review 3.  The advent of AAV9 expands applications for brain and spinal cord gene delivery.

Authors:  Robert D Dayton; David B Wang; Ronald L Klein
Journal:  Expert Opin Biol Ther       Date:  2012-04-20       Impact factor: 4.388

Review 4.  Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis.

Authors:  Andrew P Tosolini; James N Sleigh
Journal:  Front Mol Neurosci       Date:  2017-12-07       Impact factor: 5.639

5.  Targeting the full length of the motor end plate regions in the mouse forelimb increases the uptake of fluoro-gold into corresponding spinal cord motor neurons.

Authors:  Andrew Paul Tosolini; Rahul Mohan; Renée Morris
Journal:  Front Neurol       Date:  2013-05-20       Impact factor: 4.003
  5 in total

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