| Literature DB >> 21889215 |
S Malhotra1, C Morcillo-Suárez, D Brassat, R Goertsches, J Lechner-Scott, E Urcelay, O Fernández, J Drulovic, A García-Merino, F Martinelli Boneschi, A Chan, K Vandenbroeck, A Navarro, M F Bustamante, J Río, D A Akkad, G Giacalone, A J Sánchez, L Leyva, R Alvarez-Lafuente, U K Zettl, J Oksenberg, X Montalban, M Comabella.
Abstract
Recent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n=281) and non-responders (n=307) to IFNβ. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFNβ in MS patients. Copyright ÂEntities:
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Year: 2011 PMID： 21889215 DOI： 10.1016/j.jneuroim.2011.08.004
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478