OBJECTIVE: There is currently controversy over the association between serum interleukin-4 and -10 levels and head and neck squamous cell carcinoma in patients of different ethnicity. This study aimed to investigate serum levels of these cytokines in Iranian patients with this pathology, and to analyse correlations with tumour location and tumour stage at diagnosis. DESIGN: Serum cytokines levels were quantified using commercial enzyme-linked immunosorbent assays. SUBJECTS: Study groups comprised 93 untreated patients and 53 healthy donors. RESULTS: Serum interleukin-4 levels were significantly increased in patients compared with controls (p < 0.000), but were not significantly associated with tumour stage. Serum interleukin-10 levels were not raised in patients, nor associated with tumour stage. CONCLUSION: Serum levels of interleukin-4, but not -10, were increased in Iranian head and neck squamous cell carcinoma patients. These data do not support an association of these cytokines with tumour progression; this is consistent with previous findings.
OBJECTIVE: There is currently controversy over the association between serum interleukin-4 and -10 levels and head and neck squamous cell carcinoma in patients of different ethnicity. This study aimed to investigate serum levels of these cytokines in Iranian patients with this pathology, and to analyse correlations with tumour location and tumour stage at diagnosis. DESIGN: Serum cytokines levels were quantified using commercial enzyme-linked immunosorbent assays. SUBJECTS: Study groups comprised 93 untreated patients and 53 healthy donors. RESULTS: Serum interleukin-4 levels were significantly increased in patients compared with controls (p < 0.000), but were not significantly associated with tumour stage. Serum interleukin-10 levels were not raised in patients, nor associated with tumour stage. CONCLUSION: Serum levels of interleukin-4, but not -10, were increased in Iranian head and neck squamous cell carcinomapatients. These data do not support an association of these cytokines with tumour progression; this is consistent with previous findings.
Authors: Christoph Aderhold; Guido Manuel Grobschmidt; Alexander Sauter; Anne Faber; Karl Hörmann; Johannes David Schultz Journal: Oncol Lett Date: 2014-07-04 Impact factor: 2.967