OBJECTIVES: Fever of unknown origin (FUO) is dynamic in its origin and will be an ongoing challenge to the clinician because of shifting disease epidemiology. Here we present a series of patients with classical FUO admitted to an infectious diseases department during a 5-y period, with an emphasis on the diagnostic utility of ¹⁸F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) in present-day cases of FUO. METHODS: Patient records were reviewed retrospectively. RESULTS: A final diagnosis was achieved for 31 of the 52 cases (60%). The final diagnoses of these 31 cases and their distribution in the respective diagnostic categories were: infections 32% (10/31), non-infectious inflammatory disease 55% (17/31), and malignancy 13% (4/31). In our study PET/CT successfully identified an infectious, inflammatory, or neoplastic cause of fever in 10 of the 22 patients (45%) who underwent this scan. CONCLUSIONS: During the past decade the proportion of non-infectious inflammatory diseases in FUO series has increased. Based on our findings we recommend: (1) a PET/CT scan be performed early in the diagnostic work-up of patients with FUO, and (2) restraint in performing invasive procedures in patients with FUO in whom no cause of fever has been determined during diagnostic work-up.
OBJECTIVES:Fever of unknown origin (FUO) is dynamic in its origin and will be an ongoing challenge to the clinician because of shifting disease epidemiology. Here we present a series of patients with classical FUO admitted to an infectious diseases department during a 5-y period, with an emphasis on the diagnostic utility of ¹⁸F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) in present-day cases of FUO. METHODS:Patient records were reviewed retrospectively. RESULTS: A final diagnosis was achieved for 31 of the 52 cases (60%). The final diagnoses of these 31 cases and their distribution in the respective diagnostic categories were: infections 32% (10/31), non-infectious inflammatory disease 55% (17/31), and malignancy 13% (4/31). In our study PET/CT successfully identified an infectious, inflammatory, or neoplastic cause of fever in 10 of the 22 patients (45%) who underwent this scan. CONCLUSIONS: During the past decade the proportion of non-infectious inflammatory diseases in FUO series has increased. Based on our findings we recommend: (1) a PET/CT scan be performed early in the diagnostic work-up of patients with FUO, and (2) restraint in performing invasive procedures in patients with FUO in whom no cause of fever has been determined during diagnostic work-up.
Authors: Gijsbert J Blokhuis; Chantal P Bleeker-Rovers; Marije G Diender; Wim J G Oyen; Jos M Th Draaisma; Lioe-Fee de Geus-Oei Journal: Eur J Nucl Med Mol Imaging Date: 2014-05-29 Impact factor: 9.236
Authors: Jin Shang; Libo Yan; Lingyao Du; Lingbo Liang; Qiaoling Zhou; Tao Liang; Lang Bai; Hong Tang Journal: Wien Klin Wochenschr Date: 2017-01-16 Impact factor: 2.275
Authors: Hussein Mahajna; Keren Vaknin; Jennifer Ben Shimol; Abdulla Watad; Arsalan Abu-Much; Naim Mahroum; Ora Shovman; Yehuda Shoenfeld; Howard Amital; Tima Davidson Journal: Int J Environ Res Public Health Date: 2021-05-18 Impact factor: 3.390