Literature DB >> 21887847

Polyethylenimine-cyclodextrin-tegafur conjugate shows anti-cancer activity and a potential for gene delivery.

Qi-da Hu1, Hui Fan, Wei-jian Lou, Qing-qing Wang, Gu-ping Tang.   

Abstract

Polyethylenimine-cyclodextrin-tegafur (PEI-CyD-tegafur) conjugate was synthesized as a novel multifunctional prodrug of tegafur for co-delivery of chemotherapeutic agent tegafur and enhanced green fluorescent protein (EGFP) reporter plasmid DNA. Conjugation of tegafur to PEI-CyD via chemical linkage was characterized by (1)H NMR spectrometry and ultraviolet (UV) spectrometry. PEI-CyD-tegafur was able to condense plasmid DNA into complexes of around 150 nm with positive charge at the N/P ratio of 25, in accordance with electron microscopy observation of compact and monodisperse nanoparticles. The results of in vitro experiments showed enhanced cytotoxicity and considerable transfection efficiency in B16F10 cell line. Therefore, PEI-CyD-tegafur may have great potential as a co-delivery system with anti-cancer activity and potential for gene delivery.

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Year:  2011        PMID： 21887847      PMCID： PMC3167905          DOI： 10.1631/jzus.B1000307

Source DB:  PubMed          Journal:  J Zhejiang Univ Sci B        ISSN： 1673-1581            Impact factor:   3.066


  27 in total

1.  Pulmonary toxicity by a cytotoxic agent, S-1.

Authors:  Yuji Tada; Yuichi Takiguchi; Ayako Fujikawa; Atsushi Kitamura; Katsushi Kurosu; Kenzo Hiroshima; Seiichiro Sakao; Yasunori Kasahara; Nobuhiro Tanabe; Koichiro Tatsumi; Takayuki Kuriyama
Journal:  Intern Med       Date:  2007-08-02       Impact factor: 1.271

Review 2.  Nonviral vectors for gene delivery.

Authors:  Meredith A Mintzer; Eric E Simanek
Journal:  Chem Rev       Date:  2009-02       Impact factor: 60.622

3.  Preparation and characterization of tegafur magnetic thermosensitive liposomes.

Authors:  Zhaowu Zeng; Xiaoli Wang; Yangde Zhang; Xingyan Liu; Weihua Zhou; Nianfeng Li
Journal:  Pharm Dev Technol       Date:  2009       Impact factor: 3.133

4.  Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells.

Authors:  Alex M Chen; Min Zhang; Dongguang Wei; Dirk Stueber; Oleh Taratula; Tamara Minko; Huixin He
Journal:  Small       Date:  2009-12       Impact factor: 13.281

5.  Novel prodrugs of tegafur that display improved anticancer activity and antiangiogenic properties.

Authors:  Dikla Engel; Abraham Nudelman; Nataly Tarasenko; Inesa Levovich; Igor Makarovsky; Segev Sochotnikov; Igor Tarasenko; Ada Rephaeli
Journal:  J Med Chem       Date:  2007-12-29       Impact factor: 7.446

6.  The gene transfection efficiency of a folate-PEI600-cyclodextrin nanopolymer.

Authors:  Hong Yao; Samuel S Ng; Wesley O Tucker; Yuk-Kai-Tiu Tsang; Kwan Man; Xiao-Mei Wang; Billy K C Chow; Hsiang-Fu Kung; Gu-Ping Tang; Marie C Lin
Journal:  Biomaterials       Date:  2009-07-16       Impact factor: 12.479

7.  Tegafur loading and release properties of magnetite/poly(alkylcyanoacrylate) (core/shell) nanoparticles.

Authors:  José L Arias; M Adolfina Ruiz; Visitación Gallardo; Angel V Delgado
Journal:  J Control Release       Date:  2007-09-26       Impact factor: 9.776

8.  Study of carbonyl iron/poly(butylcyanoacrylate) (core/shell) particles as anticancer drug delivery systems Loading and release properties.

Authors:  José L Arias; Fernando Linares-Molinero; Visitación Gallardo; Angel V Delgado
Journal:  Eur J Pharm Sci       Date:  2007-12-23       Impact factor: 4.384

9.  Predictive value of chemotherapy-induced neutropenia for the efficacy of oral fluoropyrimidine S-1 in advanced gastric carcinoma.

Authors:  T Yamanaka; S Matsumoto; S Teramukai; R Ishiwata; Y Nagai; M Fukushima
Journal:  Br J Cancer       Date:  2007-06-05       Impact factor: 7.640

10.  [Preparation of floxuridine loaded polycation and its antitumor activity].

Authors:  Dan-Jun Zhao; Xiao Lu; Qi-Ying Jiang; Dan Chen; Jun Zhou; Hai Yu; Qing-Qing Wang; Gu-Ping Tang
Journal:  Zhejiang Da Xue Xue Bao Yi Xue Ban       Date:  2009-01
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  2 in total

Review 1.  Cyclodextrins in non-viral gene delivery.

Authors:  Wing-Fu Lai
Journal:  Biomaterials       Date:  2013-10-05       Impact factor: 12.479

2.  Low-weight polyethylenimine cross-linked 2-hydroxypopyl-β-cyclodextrin and folic acid as an efficient and nontoxic siRNA carrier for gene silencing and tumor inhibition by VEGF siRNA.

Authors:  Jin-Ming Li; Yuan-Yuan Wang; Wei Zhang; Hua Su; Liang-Nian Ji; Zong-Wan Mao
Journal:  Int J Nanomedicine       Date:  2013-06-05
  2 in total

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