Kathleen Armstrong1, Miriam Weinstein. 1. Paediatric Dermatology Hospital For Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8.
Abstract
BACKGROUND: A review of scientific literature reveals a sparse documentation of periungual pyogenic granulomas as an adverse effect of isotretinoin therapy MAIN OBSERVATIONS: Periungual pyogenic granulomas appeared in four patients receiving isotretinoin therapy for severe acne. Oral and topical antibiotic treatments were ineffective and all cases spontaneously resolved once isotretinoin is discontinued. CONCLUSION: This report demonstrates the idiosyncratic nature of this side effect. We suggest that, although infection is possible due to the transformed nature of the normally protective skin barrier, oral and topical antibiotic treatments appear ineffective. Pyogenic granulomas spontaneously resolve once isotretinoin is discontinued.
BACKGROUND: A review of scientific literature reveals a sparse documentation of periungual pyogenic granulomas as an adverse effect of isotretinoin therapy MAIN OBSERVATIONS: Periungual pyogenic granulomas appeared in four patients receiving isotretinoin therapy for severe acne. Oral and topical antibiotic treatments were ineffective and all cases spontaneously resolved once isotretinoin is discontinued. CONCLUSION: This report demonstrates the idiosyncratic nature of this side effect. We suggest that, although infection is possible due to the transformed nature of the normally protective skin barrier, oral and topical antibiotic treatments appear ineffective. Pyogenic granulomas spontaneously resolve once isotretinoin is discontinued.
Authors: J P Campbell; R C Grekin; C N Ellis; S S Matsuda-John; N A Swanson; J J Voorhees Journal: J Am Acad Dermatol Date: 1983-11 Impact factor: 11.527
Authors: Carlos Cuenca-Barrales; Teresa Ródenas-Herranz; Laura Linares-Gonzalez; Ricardo Ruiz-Villaverde Journal: Sultan Qaboos Univ Med J Date: 2018-12-19