BACKGROUND: Geographic tongue, or benign migratory glossitis, is usually an asymptomatic inflammatory disorder of the tongue mucosa of unknown etiology. It is characterized by circinate, erythematous, ulcer-like lesions of the dorsum and lateral border of the tongue due to loss of filiform papillae of the tongue epithelium. Symptomatic treatments have not been evaluated rigorously. MAIN OBSERVATION: We describe herein two cases of adult patients with persistent and painful geographic tongue successfully treated with topical application of 0.1% tacrolimus ointment. CONCLUSION: To our knowledge, this is the first report of successful treatment with topical 0.1% tacrolimus for symptomatic geographic tongue. Clinical trials are needed to confirm the efficacy and the safety of topical tacrolimus in treating geographic tongue.
BACKGROUND: Geographic tongue, or benign migratory glossitis, is usually an asymptomatic inflammatory disorder of the tongue mucosa of unknown etiology. It is characterized by circinate, erythematous, ulcer-like lesions of the dorsum and lateral border of the tongue due to loss of filiform papillae of the tongue epithelium. Symptomatic treatments have not been evaluated rigorously. MAIN OBSERVATION: We describe herein two cases of adult patients with persistent and painful geographic tongue successfully treated with topical application of 0.1% tacrolimus ointment. CONCLUSION: To our knowledge, this is the first report of successful treatment with topical 0.1% tacrolimus for symptomatic geographic tongue. Clinical trials are needed to confirm the efficacy and the safety of topical tacrolimus in treating geographic tongue.
Authors: Alan Menter; Neil J Korman; Craig A Elmets; Steven R Feldman; Joel M Gelfand; Kenneth B Gordon; Alice Gottlieb; John Y M Koo; Mark Lebwohl; Henry W Lim; Abby S Van Voorhees; Karl R Beutner; Reva Bhushan Journal: J Am Acad Dermatol Date: 2009-02-13 Impact factor: 11.527
Authors: David Aung-Din; Michael Heath; Todd Wechter; Abigail Cline; Steven R Feldman; Joseph L Jorizzo Journal: JAMA Dermatol Date: 2018-12-01 Impact factor: 10.282
Authors: Daniel Pietrzak; Aldona Pietrzak; Dorota Krasowska; Andrzej Borzęcki; Kinga Franciszkiewicz-Pietrzak; Beata Polkowska-Pruszyńska; Maja Baranowska; Kristian Reich Journal: Arch Dermatol Res Date: 2017-09-13 Impact factor: 3.017