Amytis Towfighi1, Daniela Markovic, Bruce Ovbiagele. 1. Division of Stroke and Critical Care, Department of Neurology, University of Southern California, 1510 San Pablo Street, HCC 643, Los Angeles, CA 90033, USA. towfighi@usc.edu
Abstract
BACKGROUND AND PURPOSE: Little is known about sex-specific stroke hospitalization rates among middle-aged individuals. This study assessed recent temporal trends in stroke hospitalizations among persons aged 35 to 64 years in the United States. METHODS: The Nationwide Inpatient Sample was used to identify individuals with a primary or secondary discharge diagnosis of stroke between 1997 and 2006 (n=3,161,752). Age-adjusted sex-specific rates of ischemic and hemorrhagic stroke hospitalizations were assessed among individuals aged 35 to 64 years. RESULTS: Over the study period, stroke hospitalization rates per 100 000 decreased by 10% from 66.7 to 60.3 (trend P<0.01) in men and 8% from 52.7 to 48.3 (trend P<0.001) in women. The 55- to 64-year age group drove reductions in hospitalization rates: slope (rate of change per year)=-12.3 for men and -8.9 for women (both P<0.001). Rates increased slightly in men and women aged 35 to 44 years and remained stable for persons aged 45 to 54 years. Stroke subtype analysis revealed that rates of ischemic stroke hospitalization increased and hemorrhagic stroke hospitalization remained stable among individuals aged 35 to 44 years. Rates of ischemic and hemorrhagic stroke hospitalizations remained stable among those aged 45 to 54 years and decreased among persons aged 55 to 64 years. CONCLUSIONS: From 1997 to 2006, ischemic and hemorrhagic stroke hospitalization rates declined among individuals aged 55 to 64 years and remained stable among persons aged 45 to 54 years; ischemic stroke hospitalization rates increased among individuals aged 35 to 44 years. Further studies are needed to assess and address increases in ischemic stroke hospitalizations among younger individuals.
BACKGROUND AND PURPOSE: Little is known about sex-specific stroke hospitalization rates among middle-aged individuals. This study assessed recent temporal trends in stroke hospitalizations among persons aged 35 to 64 years in the United States. METHODS: The Nationwide Inpatient Sample was used to identify individuals with a primary or secondary discharge diagnosis of stroke between 1997 and 2006 (n=3,161,752). Age-adjusted sex-specific rates of ischemic and hemorrhagic stroke hospitalizations were assessed among individuals aged 35 to 64 years. RESULTS: Over the study period, stroke hospitalization rates per 100 000 decreased by 10% from 66.7 to 60.3 (trend P<0.01) in men and 8% from 52.7 to 48.3 (trend P<0.001) in women. The 55- to 64-year age group drove reductions in hospitalization rates: slope (rate of change per year)=-12.3 for men and -8.9 for women (both P<0.001). Rates increased slightly in men and women aged 35 to 44 years and remained stable for persons aged 45 to 54 years. Stroke subtype analysis revealed that rates of ischemic stroke hospitalization increased and hemorrhagic stroke hospitalization remained stable among individuals aged 35 to 44 years. Rates of ischemic and hemorrhagic stroke hospitalizations remained stable among those aged 45 to 54 years and decreased among persons aged 55 to 64 years. CONCLUSIONS: From 1997 to 2006, ischemic and hemorrhagic stroke hospitalization rates declined among individuals aged 55 to 64 years and remained stable among persons aged 45 to 54 years; ischemic stroke hospitalization rates increased among individuals aged 35 to 44 years. Further studies are needed to assess and address increases in ischemic stroke hospitalizations among younger individuals.
Authors: Silvia Koton; Lisa Wruck; Pedro Miguel Quibrera; Rebecca F Gottesman; Sunil K Agarwal; Sydney A Jones; Jacqueline D Wright; Eyal Shahar; Josef Coresh; Wayne D Rosamond Journal: Int J Epidemiol Date: 2019-06-01 Impact factor: 7.196
Authors: Lucas Ramirez; May A Kim-Tenser; Nerses Sanossian; Steven Cen; Ge Wen; Shuhan He; William J Mack; Amytis Towfighi Journal: J Am Heart Assoc Date: 2016-05-11 Impact factor: 5.501
Authors: Xin Tong; Quanhe Yang; Matthew D Ritchey; Mary G George; Sandra L Jackson; Cathleen Gillespie; Robert K Merritt Journal: Prev Chronic Dis Date: 2019-04-25 Impact factor: 2.830