OBJECTIVE: The aim of this multireader exercise was to assess the reliability and sensitivity to change of the psoriatic arthritis magnetic resonance imaging score (PsAMRIS) in PsA patients followed for 1 year. METHODS: MRI was acquired from 12 patients with PsA before initiation of treatment and after 12 months. MR images were scored according to PsAMRIS (for synovitis, tenosynovitis, periarticular inflammation, bone marrow edema, bone erosion, and bone proliferation) under standardized conditions, in unknown chronological order. Intraobserver/interobserver reliability was examined by intraclass correlation coefficients (ICC) and sensitivity to change by standardized response means (SRM). RESULTS: The interobserver reliability of PsAMRIS was high for synovitis, tenosynovitis, periarticular inflammation, and bone edema status and change scores (interobserver ICC 0.87-0.97). The intraobserver reliability was moderate to high (ICC 0.60-0.98) for status and change scores, except for change in periarticular inflammation (ICC 0.33). PsAMRIS sensitivity to change was moderate for synovitis, tenosynovitis, and periarticular inflammation (SRM 0.5-0.8), while poor (SRM 0.1-0.3) for bone marrow edema, erosion, and bone proliferation. Rare occurrence and minimal change contributed to poor SRM and change-score ICC for bone parameters. CONCLUSION: This multireader exercise, performed under standardized conditions, confirmed PsAMRIS to have high interobserver and intraobserver reliability for hand PsA. Measures of inflammation were sensitive to change, implying that PsAMRIS may be a valuable tool for monitoring change in inflammation during PsA clinical trials.
OBJECTIVE: The aim of this multireader exercise was to assess the reliability and sensitivity to change of the psoriatic arthritis magnetic resonance imaging score (PsAMRIS) in PsA patients followed for 1 year. METHODS: MRI was acquired from 12 patients with PsA before initiation of treatment and after 12 months. MR images were scored according to PsAMRIS (for synovitis, tenosynovitis, periarticular inflammation, bone marrow edema, bone erosion, and bone proliferation) under standardized conditions, in unknown chronological order. Intraobserver/interobserver reliability was examined by intraclass correlation coefficients (ICC) and sensitivity to change by standardized response means (SRM). RESULTS: The interobserver reliability of PsAMRIS was high for synovitis, tenosynovitis, periarticular inflammation, and bone edema status and change scores (interobserver ICC 0.87-0.97). The intraobserver reliability was moderate to high (ICC 0.60-0.98) for status and change scores, except for change in periarticular inflammation (ICC 0.33). PsAMRIS sensitivity to change was moderate for synovitis, tenosynovitis, and periarticular inflammation (SRM 0.5-0.8), while poor (SRM 0.1-0.3) for bone marrow edema, erosion, and bone proliferation. Rare occurrence and minimal change contributed to poor SRM and change-score ICC for bone parameters. CONCLUSION: This multireader exercise, performed under standardized conditions, confirmed PsAMRIS to have high interobserver and intraobserver reliability for hand PsA. Measures of inflammation were sensitive to change, implying that PsAMRIS may be a valuable tool for monitoring change in inflammation during PsA clinical trials.
Authors: Nicolò Girolimetto; Pierluigi Macchioni; Ilaria Tinazzi; Luisa Costa; Rosario Peluso; Marco Tasso; Vittoria Bascherini; Olga Addimanda; Antonio Marchetta; Niccolò Possemato; Carlo Salvarani; Dennis McGonagle; Raffaele Scarpa; Francesco Caso Journal: Clin Rheumatol Date: 2019-07-13 Impact factor: 2.980
Authors: X Baraliakos; P Sewerin; E de Miguel; E Pournara; C Kleinmond; A Shekhawat; C Jentzsch; A Wiedon; F Behrens Journal: Arthritis Res Ther Date: 2022-05-16 Impact factor: 5.606
Authors: Xenofon Baraliakos; Philip G Conaghan; Maria-Antonietta D'Agostino; Walter Maksymowych; Esperanza Naredo; Mikkel Ostergaard; Georg Schett; Paul Emery Journal: Eur J Rheumatol Date: 2019-01
Authors: Ying-Qian Mo; Ze-Hong Yang; Jun-Wei Wang; Qian-Hua Li; Xin-Yun Du; T W Huizinga; X M E Matthijssen; Guang-Zi Shi; Jun Shen; Lie Dai Journal: Arthritis Res Ther Date: 2019-12-11 Impact factor: 5.156
Authors: T Yamamoto; K Fukuda; A Morita; T Kimura; H Morishima; R Goto; R Zheng; T Terui Journal: J Eur Acad Dermatol Venereol Date: 2020-05-15 Impact factor: 6.166