BACKGROUND: Myocyte injury might be involved in the progression of essential hypertension (EHT) toward heart failure (HF). However, in the absence of high-sensitivity (hs) assay, cardiac troponin T (TnT) in EHT has not been measurable. METHODS AND RESULTS: We studied 236 consecutive ambulatory patients (mean age=65.5 years; 110 men) with treated EHT (mean systolic blood pressure=134.3 mmHg, mean serum N-terminal pro-B-type natriuretic peptide=86.6 pg/ml) for mean 65.6 months. Patients with a history of HF were excluded. Single and multiple variable analyses were performed in search of clinical correlates of elevated hs-TnT (≥0.003 ng/ml). Serum concentration of hs-TnT was ≥0.003 ng/ml (mean=0.008 ng/ml) in 184 patients. By single variable analysis, age, uric acid, log-transformed N-terminal pro-B-type natriuretic peptide, brachial-ankle pulse wave velocity, Cornell electrocardiographic (ECG) voltage, and number of antihypertensive medications were associated with log-transformed hs-TnT, while hemoglobin and estimated glomerular filtration rate (eGFR) were inversely correlated with log-transformed hs-TnT. By multivariate analysis, age, eGFR and Cornell voltage were independent correlates of log-transformed hs-TnT, even after adjustment for clinical backgrounds including known prognostic biomarkers of EHT. CONCLUSIONS: hs-TnT was ≥0.003 ng/ml in 78% of patients presenting with treated EHT and independently correlated with age, renal function, and ECG voltage of hypertrophy. Copyright Â
BACKGROUND: Myocyte injury might be involved in the progression of essential hypertension (EHT) toward heart failure (HF). However, in the absence of high-sensitivity (hs) assay, cardiac troponin T (TnT) in EHT has not been measurable. METHODS AND RESULTS: We studied 236 consecutive ambulatory patients (mean age=65.5 years; 110 men) with treated EHT (mean systolic blood pressure=134.3 mmHg, mean serum N-terminal pro-B-type natriuretic peptide=86.6 pg/ml) for mean 65.6 months. Patients with a history of HF were excluded. Single and multiple variable analyses were performed in search of clinical correlates of elevated hs-TnT (≥0.003 ng/ml). Serum concentration of hs-TnT was ≥0.003 ng/ml (mean=0.008 ng/ml) in 184 patients. By single variable analysis, age, uric acid, log-transformed N-terminal pro-B-type natriuretic peptide, brachial-ankle pulse wave velocity, Cornell electrocardiographic (ECG) voltage, and number of antihypertensive medications were associated with log-transformed hs-TnT, while hemoglobin and estimated glomerular filtration rate (eGFR) were inversely correlated with log-transformed hs-TnT. By multivariate analysis, age, eGFR and Cornell voltage were independent correlates of log-transformed hs-TnT, even after adjustment for clinical backgrounds including known prognostic biomarkers of EHT. CONCLUSIONS: hs-TnT was ≥0.003 ng/ml in 78% of patients presenting with treated EHT and independently correlated with age, renal function, and ECG voltage of hypertrophy. Copyright Â
Authors: John W McEvoy; Yuan Chen; Vijay Nambi; Christie M Ballantyne; A Richey Sharrett; Lawrence J Appel; Wendy S Post; Roger S Blumenthal; Kunihiro Matsushita; Elizabeth Selvin Journal: Circulation Date: 2015-07-07 Impact factor: 29.690
Authors: Yashashwi Pokharel; Wensheng Sun; James A de Lemos; George E Taffet; Salim S Virani; Chiadi E Ndumele; Thomas H Mosley; Ron C Hoogeveen; Josef Coresh; Jacqueline D Wright; Gerardo Heiss; Eric A Boerwinkle; Biykem Bozkurt; Scott D Solomon; Christie M Ballantyne; Vijay Nambi Journal: Hypertension Date: 2014-10-27 Impact factor: 10.190
Authors: Onur Kaypakli; Mustafa Gür; Mehmet Yavuz Gözükara; Hakan Uçar; Ali Kivrak; Taner Şeker; Durmuş Yildiray Şahin; Zafer Elbasan; Caner Türkoğlu; Murat Çayli Journal: Herz Date: 2015-06-19 Impact factor: 1.443
Authors: Murat Çaylı; Mustafa Gür; Zafer Elbasan; Taner Şeker; Caner Türkoğlu; Onur Kaypaklı; Durmuş Y Şahin; Hakan Uçar; Ali Kıvrak; Nermin Y Koyunsever; Ömer Sen Journal: J Clin Hypertens (Greenwich) Date: 2013-08-07 Impact factor: 3.738