Literature DB >> 21884926

A new FOXO pathway required for leukemogenesis.

James R Downing1.   

Abstract

In cancer, the FOXO family of transcription factors functions as tumor suppressors and is directly inactivated by oncogenic signaling through the PI3K/AKT pathway. Now, Skykes et al. (2011) identify a paradoxical requirement for FOXOs in the maintenance of leukemia-initiating cells.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21884926     DOI： 10.1016/j.cell.2011.08.019

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  3 in total

1.  Genome-wide identification of microRNA signatures associated with stem/progenitor cells in Philadelphia chromosome-positive acute lymphoblastic leukemia.

Authors:  Ehsan Valiollahi; Josep Maria Ribera; Eulàlia Genescà; Javad Behravan
Journal:  Mol Biol Rep       Date:  2019-02-02       Impact factor: 2.316

2.  FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH.

Authors:  Zhilin Liu; Diego H Castrillon; Wei Zhou; Joanne S Richards
Journal:  Mol Endocrinol       Date:  2013-01-15

3.  Role of mechanical strain-activated PI3K/Akt signaling pathway in pelvic organ prolapse.

Authors:  Bing-Shu Li; Wen-Jun Guo; Li Hong; Yao-Dan Liu; Cheng Liu; Sha-Sha Hong; De-Bin Wu; Jie Min
Journal:  Mol Med Rep       Date:  2016-05-13       Impact factor: 2.952
  3 in total

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