| Literature DB >> 21884888 |
Cibele M Prado1, Linda A Jelicks, Louis M Weiss, Stephen M Factor, Herbert B Tanowitz, Marcos A Rossi.
Abstract
The cardiovascular manifestations of Chagas disease are well known. However, the contribution of the vasculature and specifically the microvasculature has received little attention. This chapter reviews the evidence supporting the notion that alterations in the microvasculature especially in the heart contribute to the pathogenesis of chagasic cardiomyopathy. These data may also be important in understanding the contributions of the microvasculature in the aetiologies of other cardiomyopathies. The role of endothelin-1 and of thromboxane A(2) vascular spasm and platelet aggregation is also discussed. Further, these observations may provide target(s) for intervention.Entities:
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Year: 2011 PMID: 21884888 PMCID: PMC3557505 DOI: 10.1016/B978-0-12-385895-5.00004-9
Source DB: PubMed Journal: Adv Parasitol ISSN: 0065-308X Impact factor: 3.870