AIM: To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes. MATERIALS AND METHODS: A comparative study of 20 Type 2 diabetes patients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS. RESULTS: pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetes patients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower β-cell function (HOMA-β; p=0.01) in diabetes patients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetes patients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups. CONCLUSION: Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetes patients.
AIM: To determine the impact of periodontitis on oxidative/inflammatory status and diabetes control in Type 2 diabetes. MATERIALS AND METHODS: A comparative study of 20 Type 2 diabetespatients with periodontitis [body mass index (BMI) 31+5], 20-age/gender-matched, non-periodontitis Type 2 diabetes controls (BMI 29+6) and 20 non-diabetes periodontitis controls (BMI 25+4) had periodontal examinations and fasting blood samples collected. Oxidative stress was determined by plasma small molecule antioxidant capacity (pSMAC) and protein carbonyl levels; inflammatory status by total/differential leucocytes, fibrinogen and high sensitivity C-reactive protein (hsCRP); diabetes status by fasting glucose, HbA1c, lipid profile, insulin resistance and secretion. Statistical analysis was performed using SPSS. RESULTS: pSMAC was lower (p=0.03) and protein carbonyls higher (p=0.007) in Type 2 diabetespatients with periodontitis compared with those without periodontitis. Periodontitis was associated with significantly higher HbA1c (p=0.002) and fasting glucose levels (p=0.04) and with lower β-cell function (HOMA-β; p=0.01) in diabetespatients. Periodontitis had little effect on inflammatory markers or lipid profiles, but Type 2 diabetespatients with periodontitis had higher levels of hsCRP than those without diabetes (p=0.004) and the lowest levels of HDL-cholesterol of all groups. CONCLUSION:Periodontitis is associated with increased oxidative stress and compromised glycaemic control in Type 2 diabetespatients.
Authors: Alliny S Bastos; Dana T Graves; Ana Paula de Melo Loureiro; Carlos Rossa Júnior; Dulcinéia Saes Parra Abdalla; Tanize do Espírito Santo Faulin; Niels Olsen Câmara; Oelisoa M Andriankaja; Silvana R P Orrico Journal: J Clin Endocrinol Metab Date: 2012-05-07 Impact factor: 5.958
Authors: Aderonke A Akinkugbe; A Sidney Barritt; Jianwen Cai; Steven Offenbacher; Bharat Thyagarajan; Tasneem Khambaty; Richard Singer; Eric Kallwitz; Gerardo Heiss; Gary D Slade Journal: J Periodontol Date: 2018-08 Impact factor: 6.993
Authors: Irundika H K Dias; Ian L C Chapple; Mike Milward; Melissa M Grant; Eric Hill; James Brown; Helen R Griffiths Journal: PLoS One Date: 2013-06-24 Impact factor: 3.240